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Evaluation of an oleic acid water-in-oil-in-water-type multiple emulsion as potential drug carriervia the enteral route

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Lipids

Abstract

A water-in-oil-in-water (W/O/W) emulsion composed of oleic acid was used as a carrier of carboxyfluorescein (CF)via the enteral route, as a model for future drug transport. The absorption of CF in the small intestine of rats given the emulsion (W/O/W group) was compared with the absorption in a group administered CF alone (CF group), and a surface-active agent in CF solution (MM group). Higher amounts of CF were absorbed in the W/O/W and MM groups than in the CF group. At 120 min, the amount of CF remaining in the intestinal tract was smaller in the MM group than in the W/O/W group. In the early period, CF excretion into bile was higher in the MM group than in the W/O/W group was higher than in the MM group (non-specific). The blood CF level was significantly higher at 240 and 360 min in the W/O/W group than in the other two groups. The highest concentration in lymph was found in the W/O/W group. The W/O/W emulsion was considered superior to the micelles because it maintained a higher blood level of CF over long periods and transferred it to the lymph. This suggests that the W/O/W emulsion is applicable as a drug carriervia the enteral route.

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Abbreviations

AUC:

area under the concentration-time curve

CF:

carboxyfluorescein

CMAX :

maximum concentration

GE:

glycerol fatty acid ester

Kel:

constant elimination rate

MM:

mixed micelles

PSM:

polyoxyethylene sorbitan monolaurate (Tween 20)

t-MAX:

time of maximum concentration

W/O/W:

water-in-oil-in-water

References

  1. Benoy, C.H., Elson, L.A., and Schneider, R. (1972)Br. J. Pharmacol. 45, 135–136.

    Google Scholar 

  2. Bordin, A.F., Kavaliunas, D.R., and Frank, S.G. (1978)Acta Pharm. Suec. 15, 1–12.

    Article  Google Scholar 

  3. Hashida, M., Egawa, M., Muranishi, S., and Sezaki, H. (1977)J. Pharmacokinet. Biopharm. 5, 225–239.

    Article  PubMed  CAS  Google Scholar 

  4. Engel, R.H., Riggi, S.J., and Fahrenbach, M.J. (1968)Nature (London) 219, 856–857.

    Article  CAS  Google Scholar 

  5. Woolfrey, S.G., Taylor, G., Kellaway, I.W., and Smith, A. (1986)J. Pharm. Pharmacol. 38, 304–306.

    PubMed  CAS  Google Scholar 

  6. Hashida, N., Murakami, M., Yoshikawa, H., Takada, K., and Muranishi, S. (1984)J. Pharm. Dyn. 7, 195–203.

    CAS  Google Scholar 

  7. Florence, A.T., and Whitehill, D. (1982)Int. J. Pharm. 11, 277–308.

    Article  CAS  Google Scholar 

  8. Matsumoto, S. (1986)J. Texture Studies 17, 141–159.

    CAS  Google Scholar 

  9. Muranushi, N., Kinugawa, M., Nakajima, Y., and Muranishi, S. (1980)Int. J. Pharm. 4, 271–279.

    Article  CAS  Google Scholar 

  10. Muranushi, N., Nakajima, Y., Kinugawa, M., Muranishi, S., and Sezaki, H. (1980)Int. J. Pharm. 4, 281–290.

    Article  CAS  Google Scholar 

  11. Muranishi, S. (1984)Meth. and Find Exptl. Clin. Pharmacol. 6, 763–772.

    CAS  Google Scholar 

  12. Takahashi, T., Ueda, S., Kono, K., and Majima, S. (1976)Cancer 38, 1507–1514.

    Article  PubMed  CAS  Google Scholar 

  13. Sugimura, H. (1987)J. Jpn. Med. Soc. Biol. Interface 18, 51–58.

    Google Scholar 

  14. Florence, A.T., and Whitehall, D. (1982)J. Pharm. Pharmacol. 11, 687–691.

    Google Scholar 

  15. Chiang, C., Fuller, G.C., Frankenfeld, J.W., and Rhodes, C.T. (1978)J. Pharm. Sci. 67, 63–66.

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. The First Department of Surgery, Hamamatsu University School of Medicine, 3600 Handa-cho, 431-31, Hamamatsu, Japan

    Noriyuki Oba, Hisao Sugimura, Yasuhiko Umehara, Masayuki Yoshida, Talzo Kimura & Takaji Yamaguchi

Authors
  1. Noriyuki Oba
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  2. Hisao Sugimura
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  3. Yasuhiko Umehara
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  4. Masayuki Yoshida
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  5. Talzo Kimura
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  6. Takaji Yamaguchi
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Oba, N., Sugimura, H., Umehara, Y. et al. Evaluation of an oleic acid water-in-oil-in-water-type multiple emulsion as potential drug carriervia the enteral route. Lipids 27, 701–705 (1992). https://doi.org/10.1007/BF02536028

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  • DOI: https://doi.org/10.1007/BF02536028

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