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Addition of long-chain polyunsaturated fatty acids to formula for very low birth weight infants

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Lipids

Abstract

Thirty-four premature infants who were appropriate for gestational age and weighing less than 1500 g at birth were fed “preemie” SMA-24 formula, “preemie” SMA-24 formula manufactured to contain C20 and C22 ω6 and ω3 fatty acids (LCPE-SMA), or expressed milk (EBM). Blood samples were drawn from a small arm vein during the first week of life and after 28 days of feeding. The fatty acid content of plasma phospholipids was determined. Infants fed SMA-24 had a high content of 18∶2ω6 in plasma phospholipids. Feeding LCPE-SMA normalized plasma phospholipid levels of C20 and C22 ω6 and ω3 fatty acids to be similar to levels of C20 and C22 ω6 and ω3 fatty acids found in infants fed EBM, and significantly higher than characteristic levels for infants fed SMA-24. Feeding LCPE-SMA or EBM results in a balanced incorporation of C20 and C22 ω6 and ω3 fatty acids into phospholipids derived from the liver or perhaps the small intestine.

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Abbreviations

EBM:

expressed breast milk

GLC:

gas-liquid chromatography

LCPE-SMA:

SMA-24 formula manufactured to contain long-chain polyenoic essential fatty acids

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Authors and Affiliations

  1. Nutrition and Metabolism Research Group, University of Alberta, 533 Newton Research Bldg., T6G 2C2, Edmonton, Alberta, Canada

    M. T. Clandinin, M. L. Garg, A. Parrott & J. Van Aerde

  2. Department of Foods and Nutrition, University of Alberta, 533 Newton Research Bldg., T6G 2C2, Edmonton, Alberta, Canada

    M. T. Clandinin, M. L. Garg & A. Parrott

  3. Department of Medicine, University of Alberta, 533 Newton Research Bldg., T6G 2C2, Edmonton, Alberta, Canada

    M. T. Clandinin

  4. Department of Pediatrics, University of Alberta, 533 Newton Research Bldg., T6G 2C2, Edmonton, Alberta, Canada

    J. Van Aerde

  5. Wyeth-Ayerst Research, 533 Newton Research Bldg., 19101-1245, Radnor, Pennsylvania, Edmonton, Alberta, Canada, T6G 2C2

    A. Hervada & E. Lien

Authors
  1. M. T. Clandinin
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  2. M. L. Garg
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  3. A. Parrott
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  4. J. Van Aerde
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  5. A. Hervada
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  6. E. Lien
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Clandinin, M.T., Garg, M.L., Parrott, A. et al. Addition of long-chain polyunsaturated fatty acids to formula for very low birth weight infants. Lipids 27, 896–900 (1992). https://doi.org/10.1007/BF02535869

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  • DOI: https://doi.org/10.1007/BF02535869

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