Abstract
For four weeks, groups of eight male and eight female F344/N rats were fed diets containing 15.5, 20, 30 or 40% of energy (en%) as fat. The fat was composed of corn oil and beef tallow with 9 en% from linoleate in all diets. Females had greater mean hepatic α-tocopherol levels, whereas males had greater plasma α-tocopherol and cholesterol concentrations. In males, the plasma ratio of α-tocopherol/cholesterol was significantly greater than in females (P<0.05). Plasma α-tocopherol increased with increasing en% fat (r=0.51,P<0.001) in both sexes, but dietary fat did not alter hepatic α-tocopherol levels. These results suggest that plasma α-tocopherol may serve as a biomarker of total dietary fat intake and that in F344/N rats gender differences affect α-tocopherol and cholesterol status.
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Abbreviations
- en%:
-
percentage of energy
- HDL:
-
high density lipoproteins
- HPLC:
-
high-pressure liquid chromatography
- LDL:
-
low density lipoproteins
- UV:
-
ultraviolet
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Chen, HW., Cook, L.R. & Hendrich, S. Gender and dietary fat affect α-tocopherol status in F344/N rats. Lipids 27, 844–846 (1992). https://doi.org/10.1007/BF02535861
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DOI: https://doi.org/10.1007/BF02535861