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Sterol metabolism studies in rats: Effects of taurodeoxycholic acid feeding on sterol metabolism

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Lipids

Abstract

Sterol metabolism studies using isotopic and chromatographic techniques were carried out in: (a) control rats fed stock chow +0.1% cholesterol (control group), and (b) rats fed stock chow +0.1% cholesterol and supplemented with 0.5% sodium taurodeoxycholate (taurodeoxycholate group). Feeding the bile acid enriched diet led to decreased acidic steroid synthesis, decreased cholesterol turnover, and cholesterol balance compared to nonsupplemented controls. There were no significant differences in fecal neutral sterol output, endogenous neutral sterol output, or cholesterol absorption between bile acid fed animals and controls. Tissue cholesterol levels (liver, plasma, and bile) in the two groups were also similar.

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References

  1. Cohen, B.I., R.F. Raicht, and E.H. Mosbach, J. Lipid Res. 18:223 (1977).

    PubMed  CAS  Google Scholar 

  2. Raicht, R.F., B.I. Cohen, and E.H. Mosbach, Gastroenterology 67:1155 (1974).

    PubMed  CAS  Google Scholar 

  3. Norman, A., Ark. Kemi 8:331 (1955).

    CAS  Google Scholar 

  4. Fieser, L., and S. Rajagopalan, J. Am. Chem. Soc. 72:5530 (1950).

    Article  CAS  Google Scholar 

  5. Cohen, B.I., R.F. Raicht, and E.H. Mosbach, Lipids 9:1024 (1974).

    Article  PubMed  CAS  Google Scholar 

  6. Cohen, B.I., R.F. Raicht, G. Salen, and E.H. Mosbach, Anal. Biochem. 64:567 (1975).

    Article  PubMed  CAS  Google Scholar 

  7. Cohen, B.I., R.F. Raicht, S. Shefer, and E.H. Mosbach, Biochim. Biophys. Acta 369:79 (1974).

    PubMed  CAS  Google Scholar 

  8. Grundy, S.M., and E.H. Ahrens, Jr., J. Lipid Res. 10:91 (1969).

    PubMed  CAS  Google Scholar 

  9. Beher, W.T., G.D. Baker, and D.G. Penney, J. Nutr. 79:523 (1963).

    PubMed  CAS  Google Scholar 

  10. Kim, D.N., K.T. Lee, J.M. Reiner, and W.A. Thomas, J. Lipid Res. 15:326 (1972).

    Google Scholar 

  11. Shefer, S., S. Hauser, V. Lapar, and E.H. Mosbach, J. Lipid Res. 14:573 (1973).

    PubMed  CAS  Google Scholar 

  12. Watt, S.M., and W.J. Simmonds, Clin. Exp. Pharm. Physiol. 3:305 (1976).

    CAS  Google Scholar 

  13. Vahouny, G.V., H.M. Gregorian, and L.R. Treadwell, Proc. Soc. Exp. Biol. Med. 101:538 (1959).

    PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Lipid Research of The Public Health Research Institute of The City of New York, Inc., 455 First Avenue, 10016, New York, New York

    Robert Franklin Raicht,  Bertram Ira Cohen, Bess Eliav & Erwin Heinz Mosbach

  2. the Manhattan Veterans Administration Hospital, 408 First Avenue, 10010, New York, New York

    Robert Franklin Raicht,  Bertram Ira Cohen, Bess Eliav & Erwin Heinz Mosbach

Authors
  1. Robert Franklin Raicht
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  2. Bertram Ira Cohen
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  3. Bess Eliav
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  4. Erwin Heinz Mosbach
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Franklin Raicht, R., Cohen, B.I., Eliav, B. et al. Sterol metabolism studies in rats: Effects of taurodeoxycholic acid feeding on sterol metabolism. Lipids 13, 605–609 (1978). https://doi.org/10.1007/BF02535823

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  • DOI: https://doi.org/10.1007/BF02535823

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