Abstract
To test for a regulatory defect in adipose triacylglycerol (essential) fatty acid mobilization in lymphoma-bearing mice, free [1-14C]linoleic acid/mouse serum albumin was injectediv into lymphoma-bearing and control mice, adapted to a reversed light cycle, and studied in three dietary states in the dark period. Mean daily food intake decreased in mice with small and large tumor burdens. Plasma free fatty acid (FFA) oxidation rates, which approximate FFA mobilization rates, were estimated by multicompartmental analysis (CONSAM). Oxidation of linoleate to CO2 was reduced significantly (85%) inad libitum fed as compared to briefly fasted control mice but not in fedvs. fasted mice with large or small tumor burdens. However, plasma FFA oxidation rates to CO2 did not differ in briefly fasted tumor-bearing and pairfed control mice. When re-fed a 250-mg test meal, briefly fasted mice with small tumors suppressed plasma free linoleic acid oxidation, as did controls. During simulated night, mildly anorexic, tumor-bearing mice with small tumor burdens mobilized essential fatty acids much faster than controls. This could explain body fat loss. The abnormally rapid rates of FFA (free linoleic acid) mobilization at night probably result from anorexia rather than from inability of food to suppress fat mobilization.
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Abbreviations
- EAT:
-
Ehrlich ascites tumor
- EFA:
-
essential fatty acid(s)
- FCR:
-
fractional catabolic rate
- FFA:
-
free fatty acid(s)
- I.D.:
-
injected dose
- LMF:
-
lipid mobilizing factor(s)
- SAAM/CONSAM:
-
computer programs used for simulation analysis and modeling
- TB:
-
tumor-bearing
- TGFA:
-
triacylglycerol fatty acid(s)
- TNF:
-
tumor necrosis factor
- VLDL:
-
very low density lipoprotein
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Kannan, R., Gan-Elepano, M. & Baker, N. Anorexic contribution to increased linoleate mobilization and oxidation in lymphoma-bearing mice. Lipids 27, 117–123 (1992). https://doi.org/10.1007/BF02535810
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DOI: https://doi.org/10.1007/BF02535810