Skip to main content
SpringerLink
Log in

Hypertension in rats does not potentiate hypercholesterolemia and aortic cholesterol deposition induced by a hypercholesterolemic diet

  • Article
  • Published:
Lipids

Abstract

The effect of a hypercholesterolemic diet (HCD) on hyperlipemia and atherogenesis was investigated using normotensive Wistar/Kyoto rats (WKY), spontaneously hypertensive rats (SHR) and stroke-prone SHR (SHRSP), with systolic blood pressures increasing in that order. Feeding an HCD diet containing cholesterol, cholate and suet induced hypercholesterolemia in all the strains examined as compared with a normal diet. The plasma cholesterol levels were significantly higher in WKY than in SHR and SHRSP fed the HCD diet. The HCD diet also induced hepatic fat deposition, particularly deposition of cholesteryl esters, a slight increase in aortic cholesterol deposition, and elevation of both monoenoic/saturated fatty acid ratios and linoleate/arachidonate ratios in tissue lipids. The changes induced in the three strains by the HCD diet were not positively correlated with blood pressures. The HCD diet affected hepatic acyl-CoA:cholesterol acyltransferase and plasma lecithin:cholesterol acyltransferase activities differently in WKY and SHR which, in addition to the induction of Δ9 desaturase, may partly account for the difference in the diet-induced changes in the fatty acid compositions of plasma cholesteryl esters. The results indicate that hypertensionper se does not stimulate the development of hypercholesterolemia and arterial cholesterol deposition induced by an HCD diet, suggesting that other factors are involved.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

Abbreviations

ACAT:

acyl-CoA:cholesterol acyltransferase

Cho:

cholesterol

ChoE:

cholesteryl esters

FFA:

free fatty acid

HCD:

hypercholesterolemic diet

LCAT:

lecithin: cholesterol acyltransferase

ND:

normal diet

PL:

phospholipid

SHR:

spontaneously hypertensive rats

SHRSP:

stroke-prone spontaneously hypertensive rats

TG:

triacylglycerols

WKY:

Wistar/Kyoto normotensive control rats

References

  1. Chobanian, A.V., and Manzur, F. (1972)J. Lipid Res. 13, 201–206.

    PubMed  CAS  Google Scholar 

  2. Rapp, J.H., Connor, W.E., Lin, D.S., Inahara, T., and Porter, M. (1983)J. Lipid Res. 24, 1329–1335.

    PubMed  CAS  Google Scholar 

  3. Smith, E.B. (1965)J. Atheroscler. Res. 5, 224–240.

    PubMed  CAS  Google Scholar 

  4. Hata, Y., and Insull, Jr., W. (1973)Jpn. Circ. J. 37, 269–275.

    PubMed  CAS  Google Scholar 

  5. Kingsbury, K.J., Brett, C., Stovold, R., Chapman, A., Anderson, J., and Morgan, D.M. (1974)Postgraduate Med. J. 50, 425–440.

    Article  CAS  Google Scholar 

  6. Buja, L.M., Kita, T., Goldstein, J.L., Watanabe, Y., and Brown, M.S. (1983)Atherosclerosis 3, 87–101.

    CAS  Google Scholar 

  7. Hough, J.L., and Zilversmit, D.B. (1986)Atherosclerosis 6, 50–56.

    CAS  Google Scholar 

  8. Brecher, P.I., and Chobanian, A.V. (1974)Circ. Res. 35, 692–701.

    PubMed  CAS  Google Scholar 

  9. Schwenke, D.C., and Zilversmit, D.B. (1987)Atherosclerosis 7, 367–377.

    CAS  Google Scholar 

  10. Chao, F.-F., Amende, L.M., Blanchette-Mackie, E.J., Skarlatos, S.I., Gamble, W., Resau, J.H., and Kruth, H.S. (1988)Am. J. Pathol. 131, 73–83.

    PubMed  CAS  Google Scholar 

  11. Nakayama, S., Sakashita, M., Tonooka, M., Gotoh, H., Yasuhara, H., and Sakamoto, K. (1982)Jpn. J. Pharmacol. 33, 279–289.

    Google Scholar 

  12. Brecher, P., and Chan, C.T. (1980)Biochim. Biophys. Acta 617, 458–471.

    PubMed  CAS  Google Scholar 

  13. Yamori, Y. (1974)Tr. Soc. Pathol. Jpn. 63, 226–227.

    Google Scholar 

  14. Yamori, Y., Hamashima, Y., Horie, R., Handa, H., and Sato, M. (1975)Jpn. Circ. J. 39, 601–609.

    PubMed  CAS  Google Scholar 

  15. Yamori, Y., Horie, R., Sato, M., and Fukase, M. (1976)Stroke 7, 120–125.

    PubMed  CAS  Google Scholar 

  16. Yamori, Y., Horie, R., Sato, M., and Fukase, M. (1976)Stroke 7, 385–389.

    Google Scholar 

  17. Hayashi, H., Ueno, K., Hori, T., Naito, Y., Shimokawa, T., and Okuyama, H. (1989)Chem. Pharm. Bull. 37, 1844–1848.

    PubMed  CAS  Google Scholar 

  18. Okamoto, K., and Aoki, K. (1963)Jpn. Circ. J. 27, 282–293.

    PubMed  CAS  Google Scholar 

  19. Yamori, Y., Nagaoka, A., and Okamoto, K. (1974)Jpn. Circ. J. 38, 1095–1100.

    PubMed  CAS  Google Scholar 

  20. Seubert, W. (1960)Biochem. Prep. 7, 80–83.

    CAS  Google Scholar 

  21. Okuyama, H., Lands, W.E.M., Christie, W.W., and Gunstone, F.D. (1969)J. Biol. Chem. 244, 6514–6519.

    PubMed  CAS  Google Scholar 

  22. Bligh, E.J., and Dyer, W.J. (1959)Can. J. Biochem. Physiol. 37, 911–917.

    PubMed  CAS  Google Scholar 

  23. Horii, T., Satouchi, K., Kobayashi, Y., Saito, K., Watanabe, S., Yoshida, Y., and Okuyama, H. (1991)J. Immunol. 147, 1607–1613.

    PubMed  CAS  Google Scholar 

  24. Eibl, H., Hill, E.E., and Lands, W.E.M. (1969)European J. Biochem. 9, 250–258.

    Article  CAS  Google Scholar 

  25. Lowry, O.H., Rosebrough, N.J., Farr, A.L., and Randall, R.J. (1951)J. Biol. Chem. 193, 265–275.

    PubMed  CAS  Google Scholar 

  26. Lichtenstein, A.H., and Brecher, P. (1980)J. Biol. Chem. 255, 9098–9104.

    PubMed  CAS  Google Scholar 

  27. Albers, J.J., Chen, C.H., and Adolphson, J.L. (1981)J. Lipid Res. 22, 1206–1213.

    PubMed  CAS  Google Scholar 

  28. Garg, M.L., Snoswell, A.M., and Sabine, J.R. (1986)Prog. Lipid Res. 25, 639–644.

    Article  PubMed  CAS  Google Scholar 

  29. Nagaoka, A., Iwatsuka, A., Suzuki, Z., and Okamoto, K. (1976)Am. J. Physiol. 230, 1354–1359.

    PubMed  CAS  Google Scholar 

  30. Shimokawa, T., Moriuchi, A., Hori, T., Saito, M., Naito, Y., Kabasawa, H., Nagae, Y., Matsubara, M., and Okuyama, H. (1988)Life Sci. 43, 2067–2075.

    Article  PubMed  CAS  Google Scholar 

  31. Uchida, K., Nomura, Y., Kadowaki, M., Takase, H., and Takeuchi, N. (1978)J. Biochem. 84, 1113–1118.

    PubMed  CAS  Google Scholar 

  32. Ueno, K., Hayashi, H., Moriuchi, A., and Okuyama, H. (1985)Biochim. Biophys. Acta 837, 173–180.

    PubMed  CAS  Google Scholar 

  33. Garg, M.L., Sebokova, E., Thompson, A.B.R., and Clandinin, M.T. (1988)Biochem. J. 249, 351–356.

    PubMed  CAS  Google Scholar 

  34. Goodman, D.S., Deykin, D., and Shiratori, T. (1963)J. Biol. Chem. 239, 1335–1345.

    Google Scholar 

  35. Sgoutas, D.S. (1970)Biochemistry 9, 1826–1833.

    Article  PubMed  CAS  Google Scholar 

  36. Swell, L., Law, M.D., and Treadwell, C.R. (1964)Arch. Biochem. Biophys. 104, 128–138.

    Article  PubMed  CAS  Google Scholar 

  37. Sgoutas, D.S. (1972)Biochemistry 11, 293–296.

    Article  PubMed  CAS  Google Scholar 

  38. Shah, S.N., Lossow, W.J., and Chaikoff, I.L. (1964)Biochim. Biophys. Acta 84, 176–181.

    PubMed  CAS  Google Scholar 

  39. Glomset, J.A. (1962)Biochim. Biophys. Acta 65, 128–135.

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Biological Chemistry, Faculty of Pharmaceutical Sciences, Nagoya City University, 3-1 Tanabedori Mizuhoku, 467, Nagoya, Japan

    Hiromi Mori, Kyohko Ishiguro & Harumi Okuyama

Authors
  1. Hiromi Mori
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Kyohko Ishiguro
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Harumi Okuyama
    View author publications

    You can also search for this author in PubMed Google Scholar

About this article

Cite this article

Mori, H., Ishiguro, K. & Okuyama, H. Hypertension in rats does not potentiate hypercholesterolemia and aortic cholesterol deposition induced by a hypercholesterolemic diet. Lipids 28, 109–113 (1993). https://doi.org/10.1007/BF02535773

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02535773

Keywords

Search

Navigation