Abstract
Various aspects of lipid metabolism were compared in Fisher 344 (F) and Sprague-Dawley (SD) rats aged 2, 6, 12, 18 and 24 months. The analyses included free and total cholesterol of serum and liver, LCAT, hepatic HMG-CoA reductase, cholesterol 7α-hydroxylase, fatty acid synthetase, acetyl CoA carboxylase and cholesterol synthesis from acetate or mevalonate. The body weight of SD rats increases with age whereas that of F rats plateaus at 9–12 months. Liver and aorta cholesterol levels were comparable for the 2 strains. Serum cholesterol varied but was usually lower in F rats. HMG-CoA reductase and cholesterol 7α-hydroxylase activities were not significantly different. Cholesterol synthesis from acetate was significantly higher only in 2-month-old F rats; synthesis from mevalonate was similar at each level. Acetyl CoA carboxylase and fatty acid synthetase activity were generally higher in F rats at every age level. The major difference between F and SD rats is in their pattern of weight gain with age. Differences in lipid metabolism are most marked between the young (2-month) rats.
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References
Carlson, L.A., S.O. Froberg and E.R. Nye, Gerontologia 14:65 (1968).
Kritchevsky, D., and S.A. Tepper, Am. J. Physiol. 207:631 (1964).
Dupont, J., M.M. Mathias and N.B. Cabacungan, Lipids 7:576 (1972).
Story, J.A., S.A. Tepper and D. Kritchevsky, Lipids 11:623 (1976).
Ishikawa, T.T., J. MacGee, J.A. Morrison and C.J. Glueck, J. Lipid Res. 15:286 (1974).
Stokke, K.T., and K.R. Norum, Scand. J. Clin. Lab. Invest. 27:21 (1971).
Shefer, S., S. Hauser and E.H. Mosbach, J. Lipid Res. 9:328 (1968).
Shefer, S., S. Hauser, V. Lapar, and E.H. Mosbach, J. Lipid Res. 13:402 (1972).
Nicolau, G., S. Shefer, G. Salen and E.H. Mosbach, J. Lipid Res. 15:146 (1974).
Ackerman, M.E., W.L. Redd, C.D. Tormanen, J.E. Hardgrave, and T.J. Scallen, J. Lipid Res. 18:408 (1977).
Hsu, R.Y., P.H.W. Butterworth and J.W. Porter, in “Methods in Enzymology,” Vol. 14, edited by J.M. Lowenstein, Academic Press, New York, NY, 1969, p. 33.
Inoue, H., and J.M. Lowenstein, in “Methods in Enzymology,” Vol. 35, edited by J.M. Lowenstein, Academic Press, New York, NY, 1975, p. 3.
Schacterle, G.R., and R.L. Pollack, Anal. Biochem. 51:654 (1973).
Nie, N.H., C.H. Hull, J.G. Jenkins, K. Steinbrenner and D.H. Bent, “Statistical Package for the Social Sciences,” 2nd Edition, McGraw-Hill, New York, NY, 1975.
Norum, K.R., Ann. Biol. Clin. 31:123 (1973).
Dupont, J., A.A. Spindler and M.M. Mathias, Age 1:93 (1978).
Dupont, J., M.M. Mathias, A.A. Spindler, and P. Janson, Age 3:19 (1980).
Hruza, Z., and Zbuzkova, Exp. Gerontol. 8:29 (1973).
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Story, J.A., Gomolinski, E., Czarnecki, S.K. et al. Age-strain interrelations in lipid metabolism of rats. Lipids 16, 87–92 (1981). https://doi.org/10.1007/BF02535679
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DOI: https://doi.org/10.1007/BF02535679