Abstract
The long chain bases of sphingomyelin from Morris hepatoma 7777 and host and control livers were analyzed by capillary gas liquid chromatography. Sphingosine (18∶1) was the major long chain base of control livers (66.5%) and hepatomas (65.6%), but hepatomas also had a high percentage (9.3 vs 4.4) of the 16∶1 homolog. Host liver had the most unusual long chain base composition, with ca. equal 16∶1 (24.4%) and 18∶1 (21.4%) and high amounts of 20-carbon bases (9.2% 20∶0 and 15.3% 20∶1). These differences may be related to the aberrant fatty acid metabolism known to occur in tumor-bearing animals. Such large perturbations in the long chain base composition of hepatic sphingomyelin are unprecedented and could have a major impact on the properties of host membranes.
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Merrill, A.H., Wang, E. & Wertz, P.W. Differences in the long chain (sphingoid) base composition of sphingomyelin from rats bearing Morris hepatoma 7777. Lipids 21, 529–530 (1986). https://doi.org/10.1007/BF02535642
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DOI: https://doi.org/10.1007/BF02535642