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Interaction between dietary proteins and lipids in the regulation of serum and liver lipids in the rabbit. Effect of fish protein

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Lipids

Abstract

Purified diets varying in dietary protein, namely casein (CA), soy protein (SP), fish protein (FP), and lipid origin (corn oil (CN), coconut oil (CO)) were fed to rabbits to evaluate the effects of protein and fat source, as well as protein-lipid interactions, on serum total, lipoprotein and hepatic lipid levels. Dietary proteins and lipids exerted a separate effect on serum total cholesterol (C), very low-density lipoprotein cholesterol (VLDL-C), and low-density lipoprotein cholesterol to high density lipoprotein cholesterol (LDL-C/HDL-C) ratio. Hence, CA increased serum cholesterol compared to SP, while coconut oil enhanced serum and VLDL-C, and decreased LDL-C/HDL-C compared to corn oil. Dietary proteins interacted with dietary lipids to modulate HDL-C levels. Thus, FP maintained a high level of HDL-C regardless of lipid origin, compared to CA and SP whose HDL-C levels were decreased by corn oil, compared to coconut oil. A dietary protein-lipid interaction was also observed in the regulation of liver cholesterol levels. Coconut oil, compared to corn oil, decreased liver cholesterol in rabbits fed FP, whereas hepatic cholesterol concentration was unaltered by dietary lipid source in CA- and SP-fed rabbits. These results demonstrate that dietary proteins act synergistically with dietary lipids to regulate cholesterol metabolism in the rabbit.

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Abbreviations

CA-CN:

casein-corn oil

CA-CO:

casein-coconut oil

C:

cholesterol

FP-CN:

fish protein-corn oil

FP-CO:

fish protein-coconut oil

GWGE:

gross weight gain efficiency

HDL:

high-density lipoproteins

LDL:

low-density lipoproteins

LPL:

lipoprotein lipase

NPD:

non-purified diet

PUFA:

polyunsaturated fatty acids

SFA:

saturated fatty acids

SP-CN:

soy protein-corn oil

SP-CO:

soy protein-coconut oil

TG:

triglycerides

VLDL:

very low-density lipoproteins

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Author notes

  1. Y. Deshaies

    Present address: Département de Physiologie, Faculté de Médecine, Université Laval, G1K 7P4, Québec, Canada

Authors and Affiliations

  1. Départment de Nutrition Humaine et de Consommation, Faculté des Sciences de L'Agriculture et de L'Alimentation, Université Laval, G1K 7P4, Québec, Canada

    N. Bergeron, Y. Deshaies, C. Lavigne & H. Jacques

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  1. N. Bergeron
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  2. Y. Deshaies
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  3. C. Lavigne
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  4. H. Jacques
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Bergeron, N., Deshaies, Y., Lavigne, C. et al. Interaction between dietary proteins and lipids in the regulation of serum and liver lipids in the rabbit. Effect of fish protein. Lipids 26, 759–764 (1991). https://doi.org/10.1007/BF02535627

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  • DOI: https://doi.org/10.1007/BF02535627

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