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Modulation of chemical carcinogenesis in rats by alkyl lysophospholipids

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Lipids

Abstract

The influence of 1-O-octadecyl-2-O-methyl-rac-glycero-3-phosphocholine (ET-18-OCH3) and 1-hexadecylmercapto-2-methoxymethyl-rac-propyl-3-phosphocholine (TLP, BM41.440) on methylnitrosourea (MNU)-induced rat mammary carcinomas and of ET-18-OCH3 on 7,12-dimethylbenzanthracene (DMBA)-induced leukemias was investigated. Both agents effectively delayed MNU-induced mammary tumor formation at high, cytotoxic dosages but TLP had no influence at low “immunomodulatory” doses. ET-18-OCH3 also significantly protected against leukemia development in DMBA-treated Long-Evans rats.

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Abbreviations

ET-18-OCH3 :

1-O-octadecyl-2-O-methyl-rac-glycero-3-phosphocholine

TLP:

1-hexadecylmercapto-2-methoxymethyl-rac-propyl-3-phosphocholine

DMBA:

7,12-dimethylbenzanthracene

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Authors and Affiliations

  1. Institute of Toxicology and Chemotherapy, German Cancer Research Institute, Im Neuenheimer Feld 280, 6900, Heidelberg, Federal Republic of Germany

    Martin R. Berger & Dietrich Schmähl

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  1. Martin R. Berger
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  2. Dietrich Schmähl
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Berger, M.R., Schmähl, D. Modulation of chemical carcinogenesis in rats by alkyl lysophospholipids. Lipids 22, 935–942 (1987). https://doi.org/10.1007/BF02535559

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  • DOI: https://doi.org/10.1007/BF02535559

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