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Distribution and metabolism of hexadecylphosphocholine in mice

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Lipids

Abstract

Distribution and metabolic fate of radiolabeled hexadecylphosphocholine (He-PC) has been studied in mice. It is demonstrated that He-PC is well-absorbed from the intestinal tract, intravenous (IV) and oral administration lead to similar distributions throughout the body, the highest accumulation of radioactivity occurs in liver, lung and kidney, and the metabolic products are radioactive choline, phosphocholine and 1,2-diacylphosphatidylcholine. The occurrence of these metabolites indicates that phospholipases C and D may be involved in He-PC breakdown.

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Authors and Affiliations

  1. Max-Planck-Institute for Biophysical Chemistry, Göttingen, Federal Republic of Germany

    E. A. M. Fleer & H. Eibl

  2. Cancer Research Center, Heidelberg, Federal Republic of Germany

    M. Berger

  3. Division of Haematology and Oncology, Department of Internal Medicine, University of Göttingen, Robert-Koch-Str. 40, D-3400, Göttingen, Federal Republic of Germany

    A. Breiser, D. -J. Kim, W. Damenz, A. drube, G. A. Nagel & C. Unger

Authors
  1. A. Breiser
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  2. D. -J. Kim
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  3. E. A. M. Fleer
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  4. W. Damenz
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  5. A. drube
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  6. M. Berger
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  7. G. A. Nagel
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  8. H. Eibl
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  9. C. Unger
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Breiser, A., Kim, D.J., Fleer, E.A.M. et al. Distribution and metabolism of hexadecylphosphocholine in mice. Lipids 22, 925–926 (1987). https://doi.org/10.1007/BF02535556

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  • DOI: https://doi.org/10.1007/BF02535556

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