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Accumulation of an alkyl lysophospholipid in tumor cell membranes affects membrane fluidity and tumor cell invasion

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Lipids

An Erratum to this article was published on 01 April 1988

Abstract

Tumor cells grown in the presence of 1-O-alkyl-2-O-methylglycero-3-phosphocholine (AMG-PC) accumulated this ether lipid in their membranes. Depending on the cell type and the dose of the compound, up to 17% of the total phospholipids of the purified plasma membranes consisted of authentic AMG-PC. Extensive incorporation of the agent resulted in a decrease in plasma membrane fluidity and inhibition of tumor cell invasiveness in embryonic chick heart fragments. The extent of AMG-PC incorporation and fluidity change was not strictly correlated with the degree to which tumor cell invasion was inhibited.

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Authors and Affiliations

  1. Oncologic Centre, Academic Hospital, Free University Brussels, Brussels, Belgium

    Guy A. Storme

  2. Division of Cell Biology, The Netherlands Cancer Institute (Antoni van Leeuwenhoek-Huis), 121 Plesmanlaan, 1066 CX, Amsterdam, The Netherlands

    Wim J. van Blitterswijk & Henk Hilkmann

Authors
  1. Wim J. van Blitterswijk
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  2. Henk Hilkmann
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  3. Guy A. Storme
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Additional information

An erratum to this article is available at http://dx.doi.org/10.1007/BF02537357.

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van Blitterswijk, W.J., Hilkmann, H. & Storme, G.A. Accumulation of an alkyl lysophospholipid in tumor cell membranes affects membrane fluidity and tumor cell invasion. Lipids 22, 820–823 (1987). https://doi.org/10.1007/BF02535537

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  • DOI: https://doi.org/10.1007/BF02535537

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