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Long chain fatty acid deficits in brain myelin sphingolipids of undernourished rat pups

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Lipids

Abstract

A restricted maternal dietary intake (40% of ad libitum intake) is known to cause myelin deficit that is accompanied by decreased amounts of individual phospholipids and sphingolipids in brain myelin of suckling rats. This communication reports the effects of the same nutritional stress on the fatty acid composition of brain myelin lipids. In myelin of 19-day-old normally fed rats, palmitate (16∶0), stearate (18∶0) and oleate (18∶1) accounted for 80–90% of all fatty acids in phosphatidylcholine, phosphatidylethanolamine and phosphatidylserine. Maternal dietary restriction resulted in deficits of total fatty acid content, but did not affect the proportional distribution of individual fatty acids among phospholipids. By contrast, longer chain (22- and 24-carbon) fatty acids accounted for more than half the fatty acid content of myelin cerebroside and sulfatide from the 19-day-old control rat pups. In undernourished rats of that age, proportions of lignocerate (24∶0) and nervonate (24∶1) in cerebroside and sulfatide were 40–50% lower than those in control rats. This, together with higher proportions of 16∶0, 18∶0 and 18∶1 and a higher ratio of C16−C20 to C22−C24 in under-nourished than in control rats, suggests an impairment in fatty acid chain elongation. Ten days of nutritional rehabilitation failed to restore the fatty acid imbalances; however, after an additional 5 days of ad libitum feeding, the experimental and control values were similar. The undernutrition results in hypomyelination, which is characterized by a proportional decrease in lignoceric and nervonic acids of sphingolipids.

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Abbreviations

PC:

phosphatidylcholine

PE:

phosphatidylethanolamine

PS:

phosphatidylserine

Cr:

cerebroside

Su:

sulfatide

References

  1. Dobbing, J. (1964)Proc. Roy. Soc. Biol. 159, 503–509.

    Article  PubMed  CAS  Google Scholar 

  2. Dobbing, J., and Widdowson, E.M. (1965)Brain 88, 357–366.

    PubMed  CAS  Google Scholar 

  3. Krigman, M.R., and Hogan, E.L. (1976)Brain Res. 107, 239–255.

    Article  PubMed  CAS  Google Scholar 

  4. Simons, S.D., and Johnston, P.V. (1976)J. Neurochem. 27, 63–69.

    Article  PubMed  CAS  Google Scholar 

  5. Yusuf, H.K.M., Haque, Z., and Mozaffar, Z. (1981)J. Neurochem. 36, 924–930.

    Article  PubMed  CAS  Google Scholar 

  6. Wiggins, R.C. (1982)Brain Res. Rev. 4, 151–175.

    Article  CAS  Google Scholar 

  7. Fuller, G.N., Johnston, D.A., and Wiggins, R.C. (1984)Brain Res. 290, 195–198.

    Article  PubMed  CAS  Google Scholar 

  8. Vitiello, R., Di Benedetta, C., and Gombos, G. (1985)Biochem. Soc. Trans. 13, 758–759.

    CAS  Google Scholar 

  9. Grigor, M.R., Allan, J.E., Carrington, J.M., Carne, A., Geursen, A., Young, D., Thompson, M.P., Haynes, E.B., and Coleman, R.A. (1987)J. Nutr. 117, 1247–1258.

    PubMed  CAS  Google Scholar 

  10. Altman, J., Das, G.D., Sudarshan, K., and Anderson, J.B. (1971)Develop. Psychobiol. 4, 55–70.

    Article  CAS  Google Scholar 

  11. Yeh, Y.-Y. (1988)J. Neurosci. Res. 19, 357–363.

    Article  PubMed  CAS  Google Scholar 

  12. O'Brien, J.S., and Sampson, E.L. (1964)J. Lipid Res. 6, 545–551.

    Google Scholar 

  13. Fishman, M.A., Madyastha, P., and Prensky, A.L. (1971)Lipids 6, 458–465.

    Article  PubMed  CAS  Google Scholar 

  14. Svennerholm, L. (1968)J. Lipid Res. 9, 570–579.

    PubMed  CAS  Google Scholar 

  15. Svennerholm, L., and Stallberg-Stenhagen, S. (1968)J. Lipid Res. 9, 215–225.

    PubMed  CAS  Google Scholar 

  16. Srinivasa Rao, P. (1979)Nutr. Metabol. 23, 136–144.

    Article  Google Scholar 

  17. Davison, A.N., and Dobbing, J. (1966)Br. Med. Bull. 22, 40–44.

    PubMed  CAS  Google Scholar 

  18. Wiggins, R.C., Miller, S.L., Benjamins, J.A., Krigman, M.R., and Morell, P. (1976)Brain Res. 107, 257–273.

    Article  PubMed  CAS  Google Scholar 

  19. Yeh, Y-Y., Zee, P., Owen, G.L., and Walker, E. (1982)J. Nutr. 112, 1162–1168.

    PubMed  CAS  Google Scholar 

  20. Norton, W.T., and Poduslo, S.E. (1973)J. Neurochem. 21, 749–757.

    Article  PubMed  CAS  Google Scholar 

  21. Folch, J., Lees, M., and Sloan-Stanley, G.H. (1957)J. Biol. Chem. 226, 497–509.

    PubMed  CAS  Google Scholar 

  22. Norton, W.T., and Autilio, L.A. (1966)J. Neurochem. 13, 213–222.

    Article  PubMed  CAS  Google Scholar 

  23. Yeh, Y-Y. (1984)J. Neurosci. Res. 11, 383–394.

    Article  PubMed  CAS  Google Scholar 

  24. Morrison, W.R., and Smith, L.M. (1964)J. Lipid Res. 5, 600–608.

    PubMed  CAS  Google Scholar 

  25. Tinoco, J., Shannon, A., Miljanich, P., Lyman, R.L., and Okey, R. (1962)Anal. Biochem. 3, 514–520.

    Article  PubMed  CAS  Google Scholar 

  26. Norton, W.T., and Poduslo, S.E. (1973)J. Neurochem. 21, 759–773.

    Article  PubMed  CAS  Google Scholar 

  27. Crawford, C.G., and Wells, M.A. (1979)Lipids 14, 757–762.

    Article  PubMed  CAS  Google Scholar 

  28. Srinivasa Rao, P. (1977)Lipids 12, 335–339.

    Article  Google Scholar 

  29. Wells, M.A., and Dittmer, J.C. (1967)Biochemistry 6, 3169–3175.

    Article  PubMed  CAS  Google Scholar 

  30. Wiggins, R.C., and Fuller, G.N. (1978)J. Neurochem. 30, 1231–1237.

    Article  PubMed  CAS  Google Scholar 

  31. Dhopeshwarker, G.A., Subramann, C., and Mead, F. (1973)Biochim. Biophys. Acta 296, 257–264.

    Google Scholar 

  32. Murad, S., and Kishimoto, Y. (1978)Arch. Biochem. Biophys. 185, 300–306.

    Article  PubMed  CAS  Google Scholar 

  33. Aeberhard, E., and Menkes, J.H. (1968)J. Biol. Chem. 243, 3834–3840.

    PubMed  CAS  Google Scholar 

  34. Bourre, J.M., Paturneau-Jouas, M.Y., Dandu, O.L., and Baumann, N.A. (1977)Eur. J. Biochem. 72, 41–47.

    Article  PubMed  CAS  Google Scholar 

  35. Kishimoto, Y., and Radin, N.S. (1959)J. Lipid Res. 1, 79–82.

    CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Biochemistry, St. Jude Children's Research Hospital, 38101, Memphis, Tennessee

    Yu-Yan Yeh

  2. Nutrition Department, The Pennsylvania State University, 125C Henderson South, 16802, University Park, PA

    Yu-Yan Yeh

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  1. Yu-Yan Yeh
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Yeh, YY. Long chain fatty acid deficits in brain myelin sphingolipids of undernourished rat pups. Lipids 23, 1114–1118 (1988). https://doi.org/10.1007/BF02535275

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  • DOI: https://doi.org/10.1007/BF02535275

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