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Dipyridamole inhibits lipid peroxidation and scavenges oxygen radicals

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Lipids

Abstract

Dipyridamole incubatedin vitro in systems which peroxidize fatty acids inhibited arachidonic acid, gammalinolenic acid and linoleic acid peroxidation. In the xanthine-xanthine-oxidase system, which produces superoxide anion, dipyridamole inhibited the reduction of cytochrome-C in a dose-dependent fashion. In systems generating hydroxyl radicals, dipyridamole reduced deoxyribose degradation in a dose-dependent manner. The study suggests that dipyridamole inhibits lipid peroxidation, probably by scavening oxygen free radicals.

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Abbreviations

BHT:

butylated hydroxytoluene

EDRT:

endothelium-derived relaxing factor

EDTA:

ethylene diamine tetraacetic acid

LOOH:

lipid hydroperoxide

MDA:

malondialdehyde

TBA:

thiobarbituric acid

TCA:

trichloroacetic acid

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Authors and Affiliations

  1. Institute of Clinica Medica, University of Rome “La Sapienza,” Policlinico Umberto I, OO161, Rome, Italy

    L. Iuliano, F. Violl, A. Ghiselli, C. Alessandri & F. Balsano

Authors
  1. L. Iuliano
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  2. F. Violl
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  3. A. Ghiselli
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  4. C. Alessandri
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  5. F. Balsano
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Iuliano, L., Violl, F., Ghiselli, A. et al. Dipyridamole inhibits lipid peroxidation and scavenges oxygen radicals. Lipids 24, 430–433 (1989). https://doi.org/10.1007/BF02535151

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  • DOI: https://doi.org/10.1007/BF02535151

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