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Response ofDrosophila tocis- andtrans-22-dehydrocholesterol: I. A survey

  • Symposium: Sterols Held at the AOCS Annual Meeting in New Orleans, LA, May 17–21, 1981
  • Published:
Lipids

Abstract

Cis- andtrans-22-dehydrocholesterol were added to media for 10 species ofDrosophila. Thecis isomer prevented normal maturation of 4 species and thetrans isomer was toxic to 9. These findings were corroborated by tests with 4 representative species on a sterol-deficient medium under axenic conditions. Addition of cholesterol to the latter overcame the toxicity of thetrans isomer.Trans-22-dehydrocholesterol may be acting as a competitive inhibitor in the metabolism of phytosterols to cholesterol or ecdysone by the insects.

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Abbreviations

Cholestanol:

5α-Cholestan-3β-ol

Cholesterol:

Cholest-5-en-3β-ol

Lathosterol:

5α-Cholest-7-en-3β-ol

cis-DHC:

Cholesta-5,22Z-dien-3β-ol

trans-DHC:

Cholesta-5,22E-dien-3β-ol

Desmosterol:

Cholesta-5,24-dien-3β-ol

22-Dehydrodesmosterol:

Cholesta-5,22E,24-trien-3β-ol

Zymosterol:

5α-Cholesta-8,24-dien-3β-ol

Brassicasterol:

Ergosta-5,22E-dien-3β-ol

5,6-Dihydroergosterol:

5α-Ergosta-7,22E-dien-3β-ol

Ergosterol:

Ergosta-5,7,22E-trien-3β-ol

Sitosterol:

Stigmast-5-en-3β-ol

Stigmasterol:

Stigmasta-5,22E-dien-3β-ol

Spinasterol:

5α-Stigmasta-7,22E dien-3β-ol

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Authors and Affiliations

  1. Department of Nutrition and Food Science, University of Arizona, 85721, Tucson, AZ

    Henry W. Kircher, Rebecca L. Phariss, Fumiko U. Rosenstein, David Baldwin & James C. Fogleman

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  1. Henry W. Kircher
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  2. Rebecca L. Phariss
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  3. Fumiko U. Rosenstein
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  4. David Baldwin
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  5. James C. Fogleman
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Additional information

Arizona Agricultural Experiment Station Journal article no. 3469.

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Kircher, H.W., Phariss, R.L., Rosenstein, F.U. et al. Response ofDrosophila tocis- andtrans-22-dehydrocholesterol: I. A survey. Lipids 17, 209–214 (1982). https://doi.org/10.1007/BF02535105

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  • DOI: https://doi.org/10.1007/BF02535105

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