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Hypercholesterolemia in rats: Combined effect of high cholesterol diet and female sex steroids

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Lipids

Abstract

The influence of estradiol and a contraceptive steroid combination on plasma cholesterol was studied in female rats on both normal and high-cholesterol diets which did not contain thiouracil. The high-cholesterol diet resulted in moderate hypercholesterolemia without weight loss, even with prolonged feeding. Hypercholesterolemia was markedly accentuated in the presence of either endogenous or exogenous sex hormones.

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Authors and Affiliations

  1. Department of Physiology, University of Pennsylvania, School of Medicine, 19104, Philadelphia

    G. M. Fischer & M. L. Swain

Authors
  1. G. M. Fischer
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  2. M. L. Swain
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Fischer, G.M., Swain, M.L. Hypercholesterolemia in rats: Combined effect of high cholesterol diet and female sex steroids. Lipids 17, 172–175 (1982). https://doi.org/10.1007/BF02535099

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  • DOI: https://doi.org/10.1007/BF02535099

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