Abstract
Glycosylceramide-sulfates were prepared separately from human kidney cortex and medulla. Glycosylceramide-sulfates were characterized with respect to long-chain bases, fatty acids, carbohydrates and sulfuric ester group position. Monogalactosylceramide I3-sulfates were 3 times more concentrated in medulla compared to cortex, whereas lactosylceramide II3-sulfates were 3 times more concentrated in cortex compared to medulla. The results were discussed in relation to the possible role of glycosyl-ceramide-sulfates in sodium-potassium ion transport.
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The IUPAC-IUB recommendations (1) for nomenclature of glycosphingolipids carrying a sulfuric ester (sulfate) group, formally called sulfatides, are used here. The IUPAC-IUB recommendations of 1970 (2) for assignment of double bond position are used here for methyl branch positions. Thus, n−3 means position 3 from the methyl end. In the short-hand designations for long-chain bases, d means dihydroxy, t means trihydroxy and br is a methyl branched chain. The number before the colon means chain length and the number after the colon is degree of unsaturation. Na+-K+-ATPase=sodium-potassium adenosine triphosphatase (EC 3.6.1.3).
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Samuelsson, B.E. Regional distribution of glycosylceramide-sulfates in human kidney. Lipids 17, 160–165 (1982). https://doi.org/10.1007/BF02535096
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DOI: https://doi.org/10.1007/BF02535096