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Absence of cholesterogenesis regulation in the liver and prostate of the BIO 87.20 hamster

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Lipids

Abstract

Normal, adult golden Syrian hamsters and the inbred stain BIO 87.20 Syrian hamsters were maintained on either control, cholesterol, candicidin or clofibrate diets for time periods of up to 4 months. The ventral prostate gland in both species was found to synthesize cholesterol at a greater rate than the liver. Also, our results show that, while hepatic cholesterol synthesis in the normal Syrian hamster is under feedback control with dietary cholesterol, hepatic cholesterol synthesis in the BIO 87.20 hamster, and prostatic cholesterol synthesis in either species, is under no such control. This apparent regulatory defect in the BIO 87.20 hamster, which results in a dramatic accumulation of cholesterol in the liver and serum, renders this animal a potentially valuable in vivo model for the study of cholesterol-related disorders.

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References

  1. Homburger, F., and Nixon, C.W. (1970) Proc. Soc. Exp. Biol. Med. 134, 284–286.

    PubMed  CAS  Google Scholar 

  2. Gordon, H.W., and Schaffner, C.P. (1968) Proc. Natl. Acad. Sci. U.S.A. 60, 1201–1208.

    Article  PubMed  CAS  Google Scholar 

  3. Keshin, J.G. (1973) Int. Surgery 58, 116–122.

    CAS  Google Scholar 

  4. Orkin, L.A. (1974) Urology 4, 80–84.

    Article  Google Scholar 

  5. Sporer, A., Cohen, S., Kamat, M.H., and Seebode, J.J. (1975) Urology 6, 298–305.

    Article  PubMed  CAS  Google Scholar 

  6. Wang, G.M., and Schaffner, C.P. (1976) Invest. Urol. 14, 66–71.

    PubMed  CAS  Google Scholar 

  7. Schaffner, C.P., and Gordon, H.W. (1968) Proc. Natl. Acad. Sci. U.S.A. 61, 36–41.

    Article  PubMed  CAS  Google Scholar 

  8. Fulton, J.E., Jr., and Hsia, S.L. (1972) J. Lipid Res. 13, 78–85.

    PubMed  CAS  Google Scholar 

  9. Parekh, A.S., and Jung, D.H. (1970) Anal. Chem. 42, 1423–1427.

    Article  CAS  Google Scholar 

  10. Sperry, W.M. (1963) J. Lipid Res. 4, 221–225.

    PubMed  CAS  Google Scholar 

  11. Ho, K.J. (1975) Proc. Soc. Exp. Biol. Med. 150, 271–277.

    PubMed  CAS  Google Scholar 

  12. Dietschy, J.M., and Siperstein, M.D. (1967) J. Lipid Res. 8, 97–104.

    PubMed  CAS  Google Scholar 

  13. Siperstein, M.D., and Guest, M.J. (1960) J. Clin. Invest. 39, 642–652.

    Article  PubMed  CAS  Google Scholar 

  14. Siperstein, M.D., and Fagan, V.M. (1966) J. Biol. Chem. 241, 602–609.

    PubMed  CAS  Google Scholar 

  15. Siperstein, M.D., Gyde, A.M., and Morris, H.P. (1971) Proc. Natl. Acad. Sci. U.S.A. 68, 315–317.

    Article  PubMed  CAS  Google Scholar 

  16. Brown, M.S., Goldstein, J.L., and Siperstein, M.D. (1973) Fed. Proc. 32, 2168–2173.

    PubMed  CAS  Google Scholar 

  17. Chen, H.W., Kandutsch, A.A., Heiniger, H.J., and Meier, H. (1973) Cancer Res. 33, 2774–2778.

    PubMed  CAS  Google Scholar 

  18. Sable-Amplis, R., Sicart, R., and Agid, R. (1978) Biochim. Biophys. Acta 531, 215–221.

    PubMed  CAS  Google Scholar 

Download references

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Authors and Affiliations

  1. Waksman Institute of Microbiology, Rutgers-The State University of New Jersey, PO Box 759, 08854, Piscataway, NJ

    Carl P. Schaffner, David R. Brill, Anil K. Singhal, Daniel P. Bonner, Neil I. Goldstein & Geng M. Wang

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  1. Carl P. Schaffner
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  2. David R. Brill
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  3. Anil K. Singhal
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  4. Daniel P. Bonner
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  5. Neil I. Goldstein
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  6. Geng M. Wang
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Schaffner, C.P., Brill, D.R., Singhal, A.K. et al. Absence of cholesterogenesis regulation in the liver and prostate of the BIO 87.20 hamster. Lipids 16, 835–840 (1981). https://doi.org/10.1007/BF02535039

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  • DOI: https://doi.org/10.1007/BF02535039

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