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Effect of water mobility on lateral diffusion of phospholipids in liposomes

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Lipids

Abstract

Recently, several studies have shown that the rate of lateral diffusion of liquid-crystalline phospholipids in various phospholipid/water lamellar systems depends markedly on the hydration over the water content of 15–40 w/w%. In this paper, we calculated the change in lipid lateral diffusion as a function of water content according to the theory of Brownian motion in thin sheets developed by Saffman and Delbrück. These calculations, based on experimental data of lipid dimensions and bulk water diffusion coefficients obtained for the egg phosphatidylcholine/water system at various water contents, clearly indicate that the dependence of lipid lateral diffusion on the hydration can be attributed primarily to the change in bulk water mobility in the multilamellar phospholipid/water system.

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References

  1. Sackmann, E., and Träuble, H. (1972) J. Am. Chem. Soc. 94, 4482–4510.

    Article  PubMed  CAS  Google Scholar 

  2. Devaux, P., and McConnell, H.M. (1972) J. Am. Chem. Soc., 94, 4475–4481.

    Article  PubMed  CAS  Google Scholar 

  3. Brulet, P., and McConnell, H.M. (1975) Proc. Natl. Acad. Sci. USA 72, 1451–1456.

    Article  PubMed  CAS  Google Scholar 

  4. Rubenstein, J.L.R., Smith, B.A., and McConnell, H.M. (1979). Proc. Natl. Acad. Sci. USA 76, 15–18.

    Article  PubMed  CAS  Google Scholar 

  5. McCown, J.T., Evans, E., Diehl, S., and Wiles, H.C. (1981) Biochemistry 20, 3134–3138.

    Article  PubMed  CAS  Google Scholar 

  6. Kuo, A-L., and Wade, C.G. (1979) Biochemistry 18, 2300–2306.

    Article  PubMed  CAS  Google Scholar 

  7. LeNeveu, D.M., Rand, R.P., Parsegian, V.A., and Gingell, G. (1977) Biophys. J. 18, 209–230.

    Article  PubMed  CAS  Google Scholar 

  8. Saffman, P.G., and Delbrück, M. (1975) Proc. Natl. Acad. Sci. USA 72, 3111–3113.

    Article  PubMed  CAS  Google Scholar 

  9. Saffman, P.G. (1976) Fluid Mech. 73, 593–602.

    Article  Google Scholar 

  10. Rigand, J.L., Gary-Bobo, C.M., and Lange, Y. (1972) Biochim. Biophys. Acta 266, 72–84.

    Article  Google Scholar 

  11. Parsegian, V.A., Fuller, N., and Rand, R.P. (1979) Proc. Natl. Acad. Sci. USA 71, 2750–2754.

    Article  Google Scholar 

  12. Nagle, J.F. (1973) Proc. Natl. Acad. Sci. USA 70, 3443–3444.

    Article  PubMed  CAS  Google Scholar 

  13. Longsworth, L.G. (1954) J. Phys. Chem. 58, 770–772.

    Article  CAS  Google Scholar 

Download references

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Authors and Affiliations

  1. Department of Biochemistry, University of Virginia School of Medicine, 22908, Charlottesville, VA

    Wen-Guey Wu & Ching-Hsien Huang

Authors
  1. Wen-Guey Wu
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  2. Ching-Hsien Huang
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Wu, WG., Huang, CH. Effect of water mobility on lateral diffusion of phospholipids in liposomes. Lipids 16, 820–822 (1981). https://doi.org/10.1007/BF02535036

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  • DOI: https://doi.org/10.1007/BF02535036

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