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Hypolipidemic effects of clofibrate and selected chroman analogs in fasted rats: I. Chow-fed animals

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Lipids

Abstract

The hypolipidemic properties of ethyl 6-chlorochroman-2-carboxylate (II), ethyl 6-phenylchroman-2-carboxylate (III) and ethyl 6-cyclohexylchroman-2-carboxylate (IV) were compared to clofibrate (I) in fasted normolipidemic rats. The chroman analog II, like its parent compound, clofibrate, reduced serum and α-lipoprotein cholesterol concentrations. Although analog III had no effect on serum cholesterol, it caused a slight elevation of α-lipoprotein cholesterol concentration. Serum free cholesterol was increased and LCAT activity was reduced in clofibrate-treated rats. The hypolipidemic agents had no consistent effect on liver lipid concentrations and liver microsomal HMG-CoA reductase activity. In addition, we have shown that drug efficacies varied directly with seasonal variations in serum lipid concentrations.

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Authors and Affiliations

  1. Division of Clinical Chemistry, Department of Pathology, College of Medicine, The Ohio State University, 43210, Columbus, OH

    M. O'Brien, S. T. Patel, H. A. I. Newman & J. C. Rice

  2. Divisions of Pharmacology, College of Pharmacy, The Ohio State University, 43210, Columbus, OH

    A. Mukhopadhyay & D. R. Feller

  3. Divisions of Medicinal Chemistry, College of Pharmacy, The Ohio State University, 43210, Columbus, OH

    S. S. Kokrady & D. T. Witiak

  4. Department of Preventive Medicine, College of Medicine, The Ohio State University, 43210, Columbus, OH

    R. R. Lanese

Authors
  1. M. O'Brien
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  2. S. T. Patel
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  3. A. Mukhopadhyay
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  4. H. A. I. Newman
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  5. D. R. Feller
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  6. S. S. Kokrady
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  7. D. T. Witiak
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  8. R. R. Lanese
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  9. J. C. Rice
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O'Brien, M., Patel, S.T., Mukhopadhyay, A. et al. Hypolipidemic effects of clofibrate and selected chroman analogs in fasted rats: I. Chow-fed animals. Lipids 16, 903–911 (1981). https://doi.org/10.1007/BF02534996

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  • DOI: https://doi.org/10.1007/BF02534996

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