Abstract
Four species ofDrosophila were tested, for two generations, for viability on media containing 13 different C27, C28 and C29 sterols with and withouttrans-22-dehydrocholesterol. Only cholesterol was effective for overcoming the toxic effect of therans derivative for all 4 species. The species varied in their ability to use the 13 sterols for growth, maturation and reproduction for 2 generations. The most tolerant species.D. pseudoobscura, could use 11 of the 13 sterols for structural and hormonal functions, whereas the most sensitive species,D. mettleri, could survive adequately on only 4 and less than adequately on another 3 of the 13 compounds. Desmosterol could not be used by any species, even for 1 generation.
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Arizona Agricultural Experiment Station journal article no. 3811.
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Kircher, H.W., Rosenstein, F.U. & Fogleman, J.C. Response ofDrosophila tocis- andtrans-22-dehydrocholesterol II. Ability of sterols other than cholesterol to overcome the toxicity of thetrans isomer. Lipids 19, 231–234 (1984). https://doi.org/10.1007/BF02534803
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DOI: https://doi.org/10.1007/BF02534803