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Alteration in membrane permeability by diacylglycerol and phosphatidylcholine containing arachidonic acid

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Lipids

Abstract

The phospholipid metabolites, stearoylarachidonylglycerol and diarachidonylglycerol, stimulate transepithelial sodium transport in frog skin epithelium. The increase in Na transport is due to an increase in the unidirectional influx of sodium, is amiloride sensitive and is prevented with pretreatment with indomethacin, mefanamic acid and phospholipase inhibitor, mepacrine. The data suggest a possible role of phospholipid metabolism and prostaglandin biosynthesis in the regulation of transepithelial ion transport.

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Authors and Affiliations

  1. Department of Pharmacology, Texas College of Osteopathic Medicine, 76107, Fort Worth, TX

    Thomas Yorio, Susana Torres & Nimnan Tarapoom

Authors
  1. Thomas Yorio
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  2. Susana Torres
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  3. Nimnan Tarapoom
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Yorio, T., Torres, S. & Tarapoom, N. Alteration in membrane permeability by diacylglycerol and phosphatidylcholine containing arachidonic acid. Lipids 18, 96–99 (1983). https://doi.org/10.1007/BF02534698

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  • DOI: https://doi.org/10.1007/BF02534698

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