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Relationship between platelet cyclooxygenase pathway and plasma malondialdehyde-like material

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Lipids

Abstract

Thrombin-induced platelet malondialdehyde (MDA) formation and plasma malondialdehyde-like material (MDA-LM) were evaluated in 12 healthy subjects before and after 1 and 7 days from aspirin (1 g) ingestion. 24 hr after aspirin administration, platelet MDA was almost abolished while MDA-LM showed a 23% decrease. Platelet MDA and plasma MDA-LM returned to baseline values 7 days after aspirin ingestion. These data suggest that platelet cyclooxygenase pathway affects only in part plasma MDA-LM. The evaluation of plasma MDA-LM before and after aspirin could be useful for evaluating in vivo platelet cyclooxygenase activation.

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Author notes

  1. F. Violi

    Present address: Cattedra I di Semeiotica Medica, University of Rome, Policlinco Umberto I, 00161, Rome, Italy

Authors and Affiliations

  1. Istituto di Clinica Medica, University of Rome, Policlinico Umberto I, 00161, Rome, Italy

    L. Iuliano, C. Cordova & F. Baslano

  2. Cattedra I di Semeiotica Medica, University of Rome, Policlinco Umberto I, 00161, Rome, Italy

    A. Ghiselli & C. Alessandri

Authors
  1. F. Violi
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  2. A. Ghiselli
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  3. C. Alessandri
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  4. L. Iuliano
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  5. C. Cordova
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  6. F. Baslano
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Violi, F., Ghiselli, A., Alessandri, C. et al. Relationship between platelet cyclooxygenase pathway and plasma malondialdehyde-like material. Lipids 20, 322–324 (1985). https://doi.org/10.1007/BF02534266

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  • DOI: https://doi.org/10.1007/BF02534266

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