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Cigarette smoke affects lipolytic activity in isolated rat lungs

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Lipids

Abstract

Isolated perfused rat lungs liberated fatty acids at a rate of 15 μmol/hr during perfusion of triglyceride-rich medium through the pulmonary vascular bed. About 80% of this activity seemed to result from lipoprotein lipase and 20% to hormone-sensitive lipase. Ventilation of the lungs with cigarette smoke instead of air during the perfusion reduced fatty acid liberation by 23%. Pre-exposure of rats to cigarette smoke for either 1 or 10 days did not cause significant changes in lung lipolytic activity compared to sham-exposed controls.

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Authors and Affiliations

  1. Department of Physiology, University of Turku, 20520, Turku 52, Finland

    Jaakko Hartiala, Eino Hietanen, hannu Toivonen & Pekka Uotila

  2. Department of Internal Medicine, University of Turku, 20520, Turku 52, Finland

    Jorma Viikari

Authors
  1. Jaakko Hartiala
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  2. Jorma Viikari
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  3. Eino Hietanen
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  4. hannu Toivonen
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  5. Pekka Uotila
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Hartiala, J., Viikari, J., Hietanen, E. et al. Cigarette smoke affects lipolytic activity in isolated rat lungs. Lipids 15, 539–543 (1980). https://doi.org/10.1007/BF02534227

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  • DOI: https://doi.org/10.1007/BF02534227

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