Skip to main content
SpringerLink
Log in

Distribution of phosphoinositides among subfractions of rat brain myelin

  • Published:
Lipids

Abstract

Rat brain myelin was separated into three subfractions, heavy, medium, and light, and the concentrations of phosphatidic acids (PA), phosphatidylinositol (PI), di- (DPI), and triphosphoinositide (TPI) in these fractions were determined. PI was evenly distributed among the fractions, and PA, DPI, and TPI occurred in highest concentrations in the “light” myelin. This result indicates that these fast metabolizing lipids play an important role in the tightly packed central lamellae of the myelin sheath.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Abdel-Latif, A.A., R.A. Akhtar, and J.N. Hawthorne, Biochem. J. 162:61 (1977).

    PubMed  CAS  Google Scholar 

  2. Tret'jak, A.G., I.M. Limarenko, G.V. Kossova, P.V. Gulak, and Yu P. Kozlov, J. Neurochem. 28:199 (1977).

    Article  PubMed  Google Scholar 

  3. White, G.L., H.U. Schellhase, and J.N. Hawthorne, J. Neurochem. 22:149 (1974).

    PubMed  CAS  Google Scholar 

  4. Schact, J., and B.W. Agranoff, J. Neurochem. 19:1417 (1972).

    Article  Google Scholar 

  5. Birnberger, A.C., K.L. Birnberger, S.G. Eliasson, and P.C. Simpson, J. Neurochem. 18:1291 (1971).

    Article  PubMed  CAS  Google Scholar 

  6. Eichberg, J., and R.M.C. Dawson, Biochem. J. 96:644 (1965).

    PubMed  CAS  Google Scholar 

  7. Eichberg, J., and G. Hauser, Biochim. Biophys. Acta 326:210 (1973).

    PubMed  CAS  Google Scholar 

  8. Shaikh, N.A., and F.B. St. C. Palmer, J. Neurochem. 26:597 (1976).

    Article  PubMed  CAS  Google Scholar 

  9. Hawthorne, J.N., and M. Kai, in “Handbook of Neurochemistry,” Edited by A. Lajtha, Plenum Press, New York, 1970, pp. 491–508.

    Google Scholar 

  10. Deshmukh, D.S., W.D. Bear, and H. Brockerhoff, J. Neurochem. 30:1191 (1978).

    PubMed  CAS  Google Scholar 

  11. Benjamin, J.A., K. Miller, and G.M. McKhann, J. Neurochem. 20:1589 (1973).

    Article  Google Scholar 

  12. McMillan, P.N., N.I. Williams, B. Kaufman, and E.D. Day, J. Neurochem. 19:1839 (1972).

    Article  PubMed  CAS  Google Scholar 

  13. Danks, D.M., and J.M. Matthiew, Life Sci. 24:1425 (1979).

    Article  PubMed  CAS  Google Scholar 

  14. Schacht, J., J. Lipid Res. 19:1063 (1978).

    PubMed  CAS  Google Scholar 

  15. Hauser, G., and J. Eichberg, Biochim. Biophys. Acta 326:201 (1973).

    PubMed  CAS  Google Scholar 

  16. Michell, R.M., J.N. Hawthorne, R. Coleman, and M.L. Karnovsky, Biochim. Biophys. Acta 210:86 (1970).

    PubMed  CAS  Google Scholar 

  17. Rouser, G., S. Fleischer, and A. Yamamoto, Lipids 5:494 (1970).

    Article  PubMed  CAS  Google Scholar 

  18. Bartlett, G.R., J. Biol. Chem. 234:466 (1959).

    PubMed  CAS  Google Scholar 

  19. Friedel, R.O., and S.M. Schanberg, J. Neurochem. 18:2191 (1971).

    Article  PubMed  CAS  Google Scholar 

  20. Soukup, J.F., R.O. Friedel, and S.M. Schanberg, J. Neurochem. 30:635 (1978).

    Article  PubMed  CAS  Google Scholar 

  21. Sims, N.R., and P.R. Carnegie, J. Neurochem. 27:769 (1976).

    Article  PubMed  CAS  Google Scholar 

  22. Palmer, F.B., and R.M.C. Dawson, Biochem. J. 111:637 (1969).

    CAS  Google Scholar 

  23. Waehneldt, T.V., J.-M. Matthieu, and V. Neahoff, Brain Res. 138:29 (1977).

    Article  PubMed  CAS  Google Scholar 

  24. Waehneldt, T.V., Brain Res. Bull. 3:37 (1978).

    Article  PubMed  CAS  Google Scholar 

  25. Miyamoto, E., J. Neurochem. 24:503 (1975).

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Institute for Basic Research in Mental Retardation, 1050 Forest Hill Road, 10314, Staten Island, NY

    D. S. Deshmukh, S. Kuizon, W. D. Bear & H. Brockerhoff

Authors
  1. D. S. Deshmukh
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. S. Kuizon
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. W. D. Bear
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. H. Brockerhoff
    View author publications

    You can also search for this author in PubMed Google Scholar

About this article

Cite this article

Deshmukh, D.S., Kuizon, S., Bear, W.D. et al. Distribution of phosphoinositides among subfractions of rat brain myelin. Lipids 15, 14–18 (1980). https://doi.org/10.1007/BF02534111

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02534111

Keywords

Search

Navigation