Abstract
Functional mapping studies using near-infrared spectroscopy have detected for the first time the existence of significant fluctuations in the concentration of cerebral oxygenated [oxy-Hb], and deoxygenated haemoglobin, [deoxy-Hb], during the resting period. The fluctuations are not related to alterations in the systemic circulatory system. The temporal pattern varies with each brain region. In some instances, the degrees of change in [oxy-Hb] and [deoxy-Hb] caused by highly integrated tasks are within this resting variation range. Thus, taking account of these fluctuations is essential to the interpretation of distribution patterns of cerebral activity.
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Cameron, O., Agranoff, B., Hichwa, R., Hutchings, G., Koeppe, K. andKumar, A. (1987): ‘A comparison of two ambient PET scanning conditions on LCBF, using a test-retest paradigm’,J. Cereb. Blood Flow Metab.,7, (suppl 1), pp. S590
Hazeki, O., andTamura, M. (1988): ‘Quantitative analysis of hemoglobin oxygenation state of rat brainin situ by near-infrared spectrophotometry’,J. Appl. Physiol.,64, pp. 796–802.
Hoshi, Y., andTamura, M. (1993a): ‘Detection of dynamic changes in cerebral oxygenation coupled to neuronal function during mental work in man’,Neurosci. Lett.,150, pp. 5–8
Hoshi, Y., andTamura, M. (1993b): ‘Dynamic multichannel near-infrared optical imaging of human brain activity’,J. Appl. Physiol.,75, pp. 1842–1846
Hoshi, Y., Onoe, H., Watanabe, Y., Andersson, J., Bergströme, M., Lilja, A., Långströme, B. andTamura, M. (1994): ‘Nonsynchronous behavior of neuronal activity, oxidative metabolism and blood supply during mental tasks in man’,Neurosci. Lett.,172, pp. 129–133
Ingvar, D. H., andRisenberg, J. (1967): ‘Increase of regional cerebral blood flow during mental effort in normals and in patients with focal brain disorders’,Exp. Brain Res.,3, pp. 195–211
Jöbsis, F. F. (1977): ‘Noninvasive, infrared monitoring of cerebral and myocardial oxygen sufficiency and circulatory parameters’,Science 198, pp. 1264–1267
Matthew, E., Anderson, P., Carson, R. E., Herscovitch, P., Pettigrew, K., Cohen, R., King, C., Johanson, C.-E. andPaul, S. M. (1993): ‘Reproducibility of resting cerebral blood flow measurement with H2 15O positron emision tomography in humans’,J. Cereb. Blood Flow Metab.,13, pp. 748–754
O'Connell, J. E. A. (1970): ‘Cerebrospinal fluid mechanics’,Proc. Roy. Soc. Med.,63, pp. 509–519
Okada, F., Tokumitsu, Y., Hoshi, Y., andTamura, M. (1993): ‘Gender- and handedness-related differences of forebrain oxygenation and hemodynamics’,Brain Res.,601, pp. 37–342
Tamura, T., Eda, H., Takada, M., andKubodera, T. (1988), ‘New instrument for monitoring hemoglobin oxygenation’,Adv. Exp. Med. Biol.,248, pp. 103–107
Villinger, A., Plank, J., Hock, C., Schleinkofer, L., andDirnagl, D. (1993): ‘Near infrared spectroscopy (NIRS): a new tool to study hemodynamic changes during activation of brain function in human adults’,Neurosci. Lett.,154, pp. 101–104
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Hoshi, Y., Tamura, M. Fluctuations in the cerebral oxygenation state during the resting period in functional mapping studies of the human brain. Med. Biol. Eng. Comput. 35, 328–330 (1997). https://doi.org/10.1007/BF02534085
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DOI: https://doi.org/10.1007/BF02534085