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Effect of catecholamines and β-blockers on linoleic acid desaturation activity

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Lipids

Abstract

The effect of catecholamines and adrenergic blocking agents on the oxidative desaturation of linoleic acid in rat liver microsomes was studied. Epinephrine (1 mg/kg/body weight) produced a significant decrease on the conversion of [1-14C]linoleic acid to γ-linolenic acid. The effect of epinephrine was blocked by single injections of the β blockers propranolol (10 mg/kg body weight) or dichloroisoproterenol 30 min before the hormone treatment. Isoproterenol (100 μg/kg body weight) produced a significant decrease on the activity of the linoleyl-CoA desaturase. The effect of the catecholamines was postulated to be mediated through β receptors by an enhancement of the intracellular levels of cyclic AMP.

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Author notes

  1. Rodolfo R. Brenner (member)

    Present address: Carrera del Investigador Cientifico of the Consejo Nacional de Investigaciones Cientificas y Técnicas, Argentina

Authors and Affiliations

  1. Instituto de Fisiología, Facultad de Ciencias Médicas, Universidad Nacional de La Plata, calle 60 y 120, La Plata, Argentina

    Irma N. T. de Gómez Dumm (member), María J. T. de Alaniz (member) & Rodolfo R. Brenner (member)

Authors
  1. Irma N. T. de Gómez Dumm
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  2. María J. T. de Alaniz
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  3. Rodolfo R. Brenner
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de Gómez Dumm, I.N.T., de Alaniz, M.J.T. & Brenner, R.R. Effect of catecholamines and β-blockers on linoleic acid desaturation activity. Lipids 13, 649–652 (1978). https://doi.org/10.1007/BF02533740

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  • DOI: https://doi.org/10.1007/BF02533740

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