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Stimulation of hepatic lipogenesis by eicosa-5,8,11,14-tetraynoic acid in mice fed a high linoleate diet

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Lipids

Abstract

Liver slices, from mice fasted for one day and then refed for three days either a 15% corn oil diet or a 15% corn oil diet containing eicosa-5,8,11,14-tetraynoic acid (TYA), were incubated with [1-14C] acetate or [3H]H2O to determine lipogenic capacity. Dietary TYA produced a twofold stimulation in fatty acid and cholesterol synthesis. TYA also caused an increase in the relative proportion of linoleate (C18∶2) and a decrease in that of arachidonate (C20∶4) in liver. Thus, (a) despite high levels of C18∶2, hepatic lipogenesis can be increased, and (b) even short term feeding of TYA can alter the hepatic fatty acid composition presumably by inhibition of arachidonate synthesis from linoleate.

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References

  1. Whitney, J.E., and S. Roberts, Am. J. Physiol. 181:446 (1955).

    PubMed  CAS  Google Scholar 

  2. Brice, E.G., R.M. Okay, and M.M. Stone, J. Biol. Chem. 218:107 (1956).

    PubMed  CAS  Google Scholar 

  3. Hill, R., J.M. Linazasoro, F. Chevallier, and I.L. Chaikoff, Ibid. 233:305 (1958).

    PubMed  CAS  Google Scholar 

  4. Allmann, D.W., and D.M. Gibson, J. Lipid Res. 6:51 (1965).

    PubMed  CAS  Google Scholar 

  5. Bortz, W., S. Abraham, and I.L. Chaikoff, J. Biol. Chem. 238:1266 (1963).

    PubMed  CAS  Google Scholar 

  6. Wiegand, R.D., G.A. Rao, and R. Reiser, J. Nutr. 103:1414 (1973).

    PubMed  CAS  Google Scholar 

  7. Musch, K., M.A. Ojakian, and M.A. Williams, Biochim. Biophys. Acta 337:343 (1974).

    PubMed  CAS  Google Scholar 

  8. Clarke, S.D., D.R. Romsos, and G.A. Leveille, Lipids 11:485 (1976).

    PubMed  CAS  Google Scholar 

  9. Bartley, J.C., and S. Abraham, Biochim. Biophys. Acta 280:258 (1972).

    PubMed  CAS  Google Scholar 

  10. Sinclair, A.J., and F.D. Collins, Ibid. 152:498 (1968).

    PubMed  CAS  Google Scholar 

  11. Smith, S., H.T. Gagne, D.R. Pitelka, and S. Abraham, Biochem. J. 115:807 (1969).

    PubMed  CAS  Google Scholar 

  12. Rao, G.A., and S. Abraham, J. Natl. Cancer Inst., 58:445 (1977).

    PubMed  CAS  Google Scholar 

  13. Coniglio, J.G., D. Buch, and W.M. Grogan, Jr., Lipids 11:143 (1976).

    Article  PubMed  CAS  Google Scholar 

  14. Krebs, H.A., and R. Henseleit, Z. Physiol. Chem. 210:33 (1932).

    CAS  Google Scholar 

  15. Miguel, S.G., and S. Abraham, Biochim. Biophys. Acta 424:213 (1976).

    PubMed  CAS  Google Scholar 

  16. Sperry, W.M., and M. Webb, J. Biol. Chem. 188:97 (1950).

    Google Scholar 

  17. Abraham, S., K.J. Matthes, and I.L. Chaikoff, Biochim. Biophys. Acta 49:268 (1961).

    Article  PubMed  CAS  Google Scholar 

  18. Rao, G.A., and S. Abraham, Lipids 10:641 (1975).

    Article  PubMed  CAS  Google Scholar 

  19. Korchak, H.M., and E.J. Masoro, Biochim. Biophys. Acta 84:750 (1964).

    PubMed  CAS  Google Scholar 

  20. Bortz, W.M., and F. Lynen, Biochem. Z. 337:505 (1963).

    PubMed  CAS  Google Scholar 

  21. Tubbs, P.K., and P.B. Garland, Biochem. J. 93:550 (1964).

    PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Bruce Lyon Memorial Research Laboratory, Children’s Hospital Medical, Center of Northern California, 94609, Oakland, CA

    S. Abraham & Hope McGrath

  2. Veteran’s Administration Hospital, 94553, Martinez, CA

    G. Ananda Rao

Authors
  1. S. Abraham
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  2. Hope McGrath
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  3. G. Ananda Rao
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Abraham, S., McGrath, H. & Ananda Rao, G. Stimulation of hepatic lipogenesis by eicosa-5,8,11,14-tetraynoic acid in mice fed a high linoleate diet. Lipids 12, 446–449 (1977). https://doi.org/10.1007/BF02533631

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  • DOI: https://doi.org/10.1007/BF02533631

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