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Hepatic triglyceride lipase deficiency in liver disease

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Lipids

Abstract

The activity of post-heparin lipases in patients with alcoholic hepatitis and viral hepatitis was evaluated. Lipoprotein lipase and hepatic triglyceride lipase were differentiated by assay under high and low salt conditions and also by separation on heparin-agarose affinity chromatography columns. The mean activity of hepatic triglyceride lipase in the sera of liver disease patients was only 21–24% of the mean of controls, but lipoprotein lipase in patients’ sera was not different from normal levels. Hepatic triglyceride lipase deficiency may partially account for the accumulation of a triglyceride-rich low density lipoprotein in liver disease.

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References

  1. Ganesan, D., and H.B. Bass, FEBS Lett. 53:1 (1975).

    Article  PubMed  CAS  Google Scholar 

  2. Krauss, R.M., R.I. Levy, and D.S. Fredrickson, J. Clin. Invest. 54:1107 (1974).

    PubMed  CAS  Google Scholar 

  3. Greten, H., B. Walter and W.V. Brown, FEBS Lett. 27:306 (1972).

    Article  CAS  Google Scholar 

  4. LaRosa, J.C., R.I. Levy, H.G. Windmueller, and D.S. Fredrickson, J. Lipid Res. 13:356 (1972).

    PubMed  CAS  Google Scholar 

  5. Greten, H., A.D. Sniderman, J.G. Chandler, D. Steinberg, and W.V. Brown, FEBS Lett. 42:157 (1974).

    Article  CAS  Google Scholar 

  6. Redgrave, T.G., J. Clin. Invest. 49:465 (1970).

    PubMed  CAS  Google Scholar 

  7. Higgins, J.M., and C.J. Fielding, Biochemistry 14:2288 (1975).

    Article  PubMed  CAS  Google Scholar 

  8. Schotz, M.C., B. Arnejo, and T. Olivecrona, Biochim. Biophys. Acta 125:485 (1966).

    PubMed  CAS  Google Scholar 

  9. Ennholm, C., W. Shaw, H. Greten, and W.V. Brown, J. Biol. Chem. 250:6756 (1975).

    Google Scholar 

  10. Olivecrona, T., G. Bengtsson, S. Marklund, U. Kindahl, and M. Hook, Fed. Proc. 36:60 (1977).

    PubMed  CAS  Google Scholar 

  11. Sabesin, S.M., H.L. Hawkins, L. Kuiken, and J.B. Ragland, Gastroenterology 75:510 (1977).

    Google Scholar 

  12. Iverius, P.H., Biochem. J. 124:677 (1971).

    PubMed  CAS  Google Scholar 

  13. Shotz, M.C., A.S. Garfinkel, R.J. Huebotter, and J.E. Stewart, J. Lipid Res. 11:68 (1970).

    Google Scholar 

  14. Ragland, J.B., H.L. Hawkins, and S.M. Sabesin, Circulation Vol. 54, Sup. 11, p. 27 (Abstract) (1976).

    Google Scholar 

  15. Müller, P., R. Fellin, J. Lambrecht, B. Agostini, H. Wieland, W. Rost, and D. Seidel, Eur. J. Clin. Invest. 4:419 (1974).

    Article  PubMed  Google Scholar 

  16. Sauar, J., J.P. Blomhoff, and E. Gjone, Clin. Chim. Acta 71:403 (1976).

    Article  PubMed  CAS  Google Scholar 

Download references

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Authors and Affiliations

  1. Division of Gastroenterology Department of Medicine, University of Tennessee Center for the Health Sciences and Veterans Administration Hospital, 38163, Memphis, Tennessee

    Michael Freeman, Lois Kuiken, James B. Ragland & Seymour M. Sabesin

Authors
  1. Michael Freeman
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  2. Lois Kuiken
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  3. James B. Ragland
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  4. Seymour M. Sabesin
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Freeman, M., Kuiken, L., Ragland, J.B. et al. Hepatic triglyceride lipase deficiency in liver disease. Lipids 12, 443–445 (1977). https://doi.org/10.1007/BF02533630

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  • DOI: https://doi.org/10.1007/BF02533630

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