Skip to main content
SpringerLink
Log in

Prevention of obesity in Avy/a mice by dehydroepiandrosterone

  • Published:
Lipids

Abstract

Dehydroepiandrosterone, a mammalian glucose-6-phosphate dehydrogenase inhibitor, preventedA vy/a mice from becoming obese. Decreased accumulation of triacylglycerol accounted for a large portion of the weight difference between treated and controlA vy/a mice. Hepatic lipogenesis as measured by3H2O incorporation into total lipid was less in the dehydroepian drosterone-treated mice. Dehydroepiandrosterone did not suppress appetite and had no apparent toxic effects at the doses used, and its weight controlling effects were reversible upon withdrawal of treatment.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Nieschlag, E., D.L. Loriaux, H.J. Ruder, I.R. Zucker, M.A. Kirschner, and M.B. Lipsett, J. Endocrinol. 57:123 (1973).

    PubMed  CAS  Google Scholar 

  2. Doouss, T.W., S.J.M. Skinner, and R.A.F. Couch, Ibid. 66:1 (1975).

    PubMed  CAS  Google Scholar 

  3. Marks, P.A., and J. Banks, Proc. Nat. Acad. Sci. 46:447 (1960).

    Article  PubMed  CAS  Google Scholar 

  4. McKerns, K.W., and E. Kaleita, Biochem. Biophys. Res. Comm. 2:344 (1960).

    Article  Google Scholar 

  5. Criss, W.E., and K.W. McKerns, Biochim. Biophys. Acta 184:486 (1969).

    PubMed  CAS  Google Scholar 

  6. Raineri, R., and H.R. Levy, Biochemistry 9:2233 (1970).

    Article  PubMed  CAS  Google Scholar 

  7. Oertel, G.W., and I. Rebelein, J.Steroid Biochem. 1:93 (1970).

    Article  CAS  Google Scholar 

  8. Oertel, G.W., P. Menzel, and D. Bauke, Clin. Chim. Acta 27:197 (1970).

    Article  PubMed  CAS  Google Scholar 

  9. Oertel, G.W., and P. Benes, J. Steroid Biochem. 3:493 (1972).

    Article  PubMed  CAS  Google Scholar 

  10. Beitner, R., and Z. Naor, Biochim. Biophys. Acta 286:437 (1972).

    PubMed  CAS  Google Scholar 

  11. Lopez-S, A., and A. Rene, Proc. Soc. Exp. Biol. Med. 142:258 (1973).

    PubMed  CAS  Google Scholar 

  12. Setchenska, M.S., E.M. Russanov, and J.G. Vassileva-Popova, FEBS Lett. 49:297 (1975).

    Article  PubMed  CAS  Google Scholar 

  13. Lane, M.D., and J. Moss, in “Metabolic Pathways,” Vol. 5, Edited by H.J. Vogel, Academic Press, New York, NY, 1971, p. 23.

    Google Scholar 

  14. Sonka, J., and J. Gregorova, Acta Univ. Carolinae 1:89 (1963).

    Google Scholar 

  15. Lopez-S. A., and W.A. Krehl, Lancet 2:485 (1967).

    Article  PubMed  CAS  Google Scholar 

  16. Sonka, J., and J. Gregorova, J. Physiol. Paris, 56:650 (1965).

    Google Scholar 

  17. Willmer, J.S., and T.S. Foster, Can. J. Biochem. 43:1375 (1965).

    Article  CAS  Google Scholar 

  18. Lopez-S., A., and W.A. Krehl, Proc. Soc. Exp. Biol. Med. 126:776 (1967).

    Google Scholar 

  19. Tepperman, H.M., S.A. De la Garza, and J. Tepperman, Am. J. Physiol. 214:1126 (1968).

    PubMed  CAS  Google Scholar 

  20. Hilgertová, J., and J. Šonka, Horm. Metab. Res. 5:286 (1973).

    Article  PubMed  Google Scholar 

  21. Tsutsui, E.A., P.A. Marks, and P. Reich, J. Biol. Chem. 237:3009 (1962).

    PubMed  CAS  Google Scholar 

  22. Ziboh, V.A., M.A. Dreize, and S.L. Hsia, J. Lipid Res. 11:346 (1970).

    PubMed  CAS  Google Scholar 

  23. Yen, T.T., J.A. Allan, D.V. Pearson, J.M. Acton, and M.M. Greenberg, Fed. Proc. 33:1156 (1977).

    Google Scholar 

  24. Yen, T.T., J. Allan, P.L. Yu, M.A. Acton, and D.V. Pearson, Biochim. Biophys. Acta 441:213 (1976).

    PubMed  CAS  Google Scholar 

  25. Kandutsch, A.A., D.L. Coleman, and S.E. Alpert, Experientia 28:473 (1972).

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. The Lilly Research Laboratories, Eli Lilly and Company, 46206, Indianapolis, IN

    Terence T. Yen, Jean A. Allan, Donovan V. Pearson, June M. Action & Mark M. Greenberg

Authors
  1. Terence T. Yen
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Jean A. Allan
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Donovan V. Pearson
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. June M. Action
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Mark M. Greenberg
    View author publications

    You can also search for this author in PubMed Google Scholar

About this article

Cite this article

Yen, T.T., Allan, J.A., Pearson, D.V. et al. Prevention of obesity in Avy/a mice by dehydroepiandrosterone. Lipids 12, 409–413 (1977). https://doi.org/10.1007/BF02533624

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02533624

Keywords

Search

Navigation