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The conversion of phosphatidylethanolamine into phosphatidylcholine labeled in the choline group using methyl lodide, 18-crown-6 and potassium carbonate

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Lipids

Abstract

A chemical method for the conversion of phosphatidylethanolamine into phosphatidylcholine is described. Methyl iodide in the presence 18-crown-6 (1,4,7,10,13,16-hexaoxacyclooctadecane) and potassium carbonate in benzene is used to alkylate phosphatidylethanolamine in 2.5 hr at 37 C to give an isotopically enriched phosphatidylcholine. The product is purified conventionally and is obtained in 75% yield.

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Author notes

  1. J. D. Morrisett (Established Investigator) & J. T. Sparrow (Established Investigator)

    Present address: American Heart Association, USA

Authors and Affiliations

  1. Department of Medicine, Baylor College of Medicine and The Methodist Hospital, 77030, Houston, Texas

    K. M. Patel, J. D. Morrisett (Established Investigator) & J. T. Sparrow (Established Investigator)

Authors
  1. K. M. Patel
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  2. J. D. Morrisett
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  3. J. T. Sparrow
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Patel, K.M., Morrisett, J.D. & Sparrow, J.T. The conversion of phosphatidylethanolamine into phosphatidylcholine labeled in the choline group using methyl lodide, 18-crown-6 and potassium carbonate. Lipids 14, 596–597 (1979). https://doi.org/10.1007/BF02533539

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  • DOI: https://doi.org/10.1007/BF02533539

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