Abstract
Approximately 20% of the phosphatidylglycerol of the lung tissue of several animals was found to have both fatty acids saturated. Pulmonary washings from the lung of the rabbit and guinea pig had more saturated phosphatidylglycerol than the washed lung tissue. Lung-saturated phosphatidylglycerol was relatively low in the perinatal period, a time during which saturated phosphatidylcholine accumulated predominantly. This suggests that the metabolism of the saturated species of lung phosphatidylcholine and phosphatidylglycerol, which are considered to be the major pulmonary surfactants, may not be regulated in the same manner, at least in the perinatal lung.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Brown, E.S., Am. J. Physiol. 207:402 (1964).
Henderson, R.F., and R.C. Pfleger, Lipids 7:492 (1972).
Pfleger, R.C., R.F. Henderson, and J. Waide, Chem. Phys. Lipids 9:51 (1972).
Hallman, M., and L.J. Gluck, J. Lipid Res. 17:257 (1976).
Rooney, S.A., P.M. Canavan, and E.K. Motoyama, Biochim. Biophys. Acta 360:56 (1974).
Sanders, R.L., and W.J. Longmore, Biochemistry 14:835 (1975).
Akino, T., T. Kawamoto, and K. Ohno, Tohoku J. Exp. Med. 124:307 (1978).
King, R.J., D.J. Klass, E.G. Gikas, and J.A. Clements, Am. J. Physiol. 224:788 (1973).
Harwood, J.L., R. Desai, P. Hext, T. Tetley, and R. Richards, Biochem. J. 151:707 (1975).
Okano, G., T. Kawamoto, and T. Akino, Biochim. Biophys. Acta 528:385 (1978).
Okano, G., and T. Akino, Biochim. Biophys. Acta 528:373 (1978).
Folch, J., M. Lees, and G.H. Sloane-Stanley, J. Biol. Chem. 227:497 (1957).
Bligh, E.G., and W.J. Dyer, Can. J. Biochem. Physiol. 37:911 (1959).
Akino, T., M. Abe, and T. Arai, Biochim. Biophys. Acta 248:274 (1971).
Rouser, G., G. Kritchevsky, A. Yamamoto, G. Simon, C. Galli, and A.J. Bauman, Methods Enzymol. 14:272 (1969).
Kuksis, A., L. Marai, W.C. Breckenridge, D.A. Gornall, and O. Stachnyk, Can. J. Physiol. Pharmacol. 46:511 (1968).
Arvidson, G.A.E., Eur. J. Biochem. 4:478 (1968).
Bartlett, G.R., J. Biol. Chem. 234:466 (1959).
Van Handel, E., and D.B. Zilversmit, J. Lab. Clin. Med. 50:152 (1957).
Schneider, W.C., Methods Enzymol. 3:680 (1957).
Morrison, W.R., and L.M. Smith, J. Lipid Res. 5:600 (1964).
Toshima, N., and T. Akino, Tohoku J. Exp. Med. 108:253 (1972).
Ohno, K., T. Akino, and T. Fujiwara, Rev. Perinatal Med. 2:227 (1978).
Tierney, D.F., J.A. Clements, and H.J. Trahan, Am. J. Physiol. 213:671 (1967).
Vereyken, J.M., A. Montfoort, and L.M.G. van Golde, Biochim. Biophys. Acta 260:70 (1972).
Hallman, M., and L. Gluck, J. Lipid Res. 17:257 (1976).
Blackburn, W.R., In “Respiratory Distress Syndrome,” Academic Press, New York, 1973, p. 271.
Hallman, M., and L. Gluck, Biochim. Biophys. Acta 409:172 (1975).
Hallman, M., and K. Raivio, Pediatr. Res. 8:874 (1974).
Oldenborg, V., and L.M.G. van Golde, Biochim. Biophys. Acta 441:433 (1976).
Brumley, G., and H. van den Bosch, J. Lipid Res. 18:523 (1977).
Author information
Authors and Affiliations
About this article
Cite this article
Okano, G., Akino, T. Variations in the molecular species of lung phosphatidylglycerol. Lipids 14, 541–546 (1979). https://doi.org/10.1007/BF02533529
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF02533529