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The formation of phosphatidylinositol by acylation of 2-acyl-sn-glycero-3-phosphorylinositol in rat liver microsomes

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Lipids

Abstract

The conversion of 2-acyl-sn-glycero-3-phosphorylinositol into phosphatidylinositol via acyl-CoA: 2-acyl-sn-glycero-3-phosphorylinositol acyltransferase activity was found to occur in rat liver microsomes. Over a wide range of conditions, stearic acid was preferred over palmitate by the acyltransferase when these acids were presented in mixtures as acyl-CoA derivatives. The potential importance of this enzyme activity for the entry of stearic acid into the 1-position of hepatic phosphatidylinositol is further supported by its greater preference for stearate relative to the acyl-CoA: 2-acyl-sn-glycero-3-phosphorylcholine acyltransferase under certain assay conditions.

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Authors and Affiliations

  1. Department of Nutrition, College of Biological Science, University of Guelph, N1G 2W1, Guelph, Ontario, Canada

    Bruce J. Holub & Jerry Piekarski

Authors
  1. Bruce J. Holub
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  2. Jerry Piekarski
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Holub, B.J., Piekarski, J. The formation of phosphatidylinositol by acylation of 2-acyl-sn-glycero-3-phosphorylinositol in rat liver microsomes. Lipids 14, 529–532 (1979). https://doi.org/10.1007/BF02533526

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  • DOI: https://doi.org/10.1007/BF02533526

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