Abstract
Total lipoproteins as well as fractionated VLDL+LDL and HDL from fasted control rats and bileligated rats were tested in liver perfusion for their effect on 3-hydroxy-3-methylglutaryl CoA reductase to increase 3-hydroxy-3-methylglutaryl CoA reductase activity than that of the control total lipoproteins. When the fractionated lipoproteins were tested from fasted control rats, it was found that the major stimulating activity was in the HDL fraction with minor activity in the VLDL+LDL fraction. When these plasma components isolated from fasted bile-ligated rats were tested, it was found that the major activity had shifted to the VLDL+LDL fraction with the HDL having only a minor stimulatory role. The possible mechanism of action of the abnormal lipoproteins associated with bile obstruction in regulating 3-hydroxy-3-methylglutaryl CoA reductase activity is discussed.
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Nervi, F.O., H. Weis, and J.M. Dietschy, J. Biol. Chem. 250:4145 (1975).
Andersen, J.M., F.O. Nervi, and J.M. Dietschy, Biochim. Biophys. Acta. 486:298 (1977).
Sherrill, B.C., and J.M. Dietschy, J. Biol. Chem. 253:1859 (1978).
Cooper, A.D., Biochim. Biophys. Acta. 488:464 (1977).
Jakoi, L., and S.H. Quarfordt, J. Biol. Chem. 252:6856 (1977).
Flint, A., Am. J. Med. Sci. 44:305 (1862).
Widel, F., A. Weill, and M. Laudat, Sem. Med. 32:529 (1912).
Chanutin, A., and S. Ludewig, J. Biol. Chem. 115:1 (1936).
Frederickson, D.S., A.V. Laud, B.T. Hinkelman, H.S. Schneider, and I.D. Frantz, J. Exp. Med. 99:43 (1954).
Ferris, R.M., H.P. Jacobi, and A.J. Barak, Lipids 7:20 (1972).
Picard, J., and D. Veissiere, Clin. Chim. Acta 30:149 (1970).
Switzer, S., J. Clin. Invest. 46:1855 (1967).
Muller, P., V. Fauser, R. Fellin, H. Wieland, and D. Seidel, FEBS Lett. 38:53 (1973).
Hinton, R.H., and B.M. Mullock, Clin. Chim. Acta 82:31 (1978).
Goodwin, C.D., and S. Margolis, J. Lipid. Res. 17:297 (1976).
Lowry, O.H., N.J. Rosebrough, A.L. Farr, and R.J. Randall, J. Biol. Chem. 193:265 (1951).
Havel, R.J., H.A. Eder, and J.H. Bragdon, J. Clin. Invest. 34:1345 (1955).
Zak, B., Am. J. Clin. Pathol. 27:583 (1957).
Breslow, J.L., D.A. Lothrop, A.W. Clowes, and S.E. Lux, J. Biol. Chem. 252:2726 (1977).
McIntyre, N., D.W. Harry, and A.J.G. Pearson, GUT 16:379 (1975).
Brown, M.S., S.E. Dana, and J.L. Goldstein, Proc. Natl. Acad. Sci. USA 70:2162 (1973).
Edwards, P., Fed. Proc. 33:1346 (1974).
Mahley, R.W., and T.L. Innerarity, J. Biol. Chem. 252:3980 (1977).
Brown, M.S., J.R. Faust, and J.L. Goldstein, J. Clin. Invest. 55:783 (1975).
Hinton, R.H., and B.M. Mullock, Clin. Chim. Acta 82:31 (1978).
Calandra, S., M. Montaguti, V. Cartoni, and I. Pasquali-Ronchetti, Biochim. Biophys. Acta 409:1 (1975).
Seidel, D., P. Alavpovic, and R.H. Furman, J. Clin. Invest. 48:1211 (1969).
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Barak, A.J., Sorrell, M.F. & Tuma, D.J. Effect of serum lipoproteins of bile obstructed rats on 3-hydroxy-3-methylglutaryl coenzyme A reductase activity in perfused rat liver. Lipids 14, 883–887 (1979). https://doi.org/10.1007/BF02533500
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DOI: https://doi.org/10.1007/BF02533500