Abstract
The metabolism of [1-14C]eicosa-11,14-dienoic acid was investigated in human testes using whole tissue minces and microsomal preparations. Both types of preparations catalyzed the desaturation of the labeled diene to eicosa-8,11,14-trienoic as well as eicosa-5,11,14-trienoic acid. The reported results, therefore, indicate that human testicular tissue, as well as rat testicular tissue (reported previously), is capable of utilizing eicosa-11,14-dienoic acid as a precursor of arachidonic acid. Since it is known that there is no Δ8 desaturase activity in rat liver and brain, these studies support the concept that there is a tissue variation in this enzymatic pathway.
Similar content being viewed by others
References
Coniglio, J.G., W.M. Grogan, Jr., and R.K. Rhamy, Biol. Reprod. 12:255 (1975).
Coniglio, J.G., W.M. Grogan, Jr., and R.K. Rhamy, J. Reprod. Fert. 51:463 (1977).
Mead, J.F., Fed. Proc. 20:952 (1961).
Klenk, E., and H. Mohrhauer, Z. Physiol. Chem. 320:218 (1960).
Ullman, D., and H. Sprecher, Biochim. Biophys. Acta 248:186 (1971).
Dhopeshwarkar, G.A., and C. Subramanian, J. Neurochem. 26:1175 (1976).
Albert, D.H., and J.G. Coniglio Biochim. Biophys. Acta 489:390 (1977).
Nakazawa, I., J.F. Mead, and R.H. Yonemoto, Lipids 11:79 (1976).
Bieri, J.G., and E.L. Prival, Comp. Biochem. Physiol. 15:275 (1965).
Peluffo, R.O., S. Ayala, and R.R. Brenner, Am. J. Physiol. 218:669 (1970).
Ayala, S., G. Gasper, R.R. Brenner, R.O. Peluffo, and W. Kunau, J. Lipid Res. 14:296 (1973).
Schlenk, H., D.M. Sand, and J.L. Gellerman, Lipids 5:575 (1970).
Gurr, M.I., M.P. Robinson, A.T. James, L.J. Morris, and D. Howling, Biochim. Biophys. Acta 280:415 (1972).
James, A.T., Adv. Exp. Med. Biol. 83:51 (1977).
Author information
Authors and Affiliations
About this article
Cite this article
Albert, D.H., Rhamy, R.K. & Coniglio, J.G. Desaturation of eicosa-11,14-dienoic acid in human testes. Lipids 14, 498–500 (1979). https://doi.org/10.1007/BF02533468
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF02533468