Abstract
The nature and content of lipid epoxides in rat lung were examined in air-breathing control rats and those exposed to nitrogen dioxide. Exposure to 6.5 ppm NO2 for 24 hr resulted in significantly greater epoxide content in a number of lipid classes. It is proposed that lipid autoxidation in lung tissues may contribute to the levels of epoxide-containing lipids. Furthermore, the processes involved in epoxide formation may be predicted from autoxidation studies utilizing a system of unsaturated fatty acid monolayers on silica gel which serves as a model for biomembranes. The findings indicate that exposure to oxidizing gases can lead to an accumulation of lipid epoxides in both lung parenchymal tissue and on the alveolar surface.
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Sevanian, A., Mead, J.F. & Stein, R.A. Epoxides as products of lipid autoxidation in rat lungs. Lipids 14, 634–643 (1979). https://doi.org/10.1007/BF02533449
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DOI: https://doi.org/10.1007/BF02533449