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Levels of cyclic 3′-5′-adenosine monophosphate (cAMP) in maintenance cultures of rat hepatocytes in response to insulin and glucagon

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Lipids

Abstract

Under conditions of short-term stimulation of lipogenesis by insulin in maintenance cultures of hepatocytes from starved rats, basal levels of cyclic 3′-5′-adenosine monophosphate (cAMP) are invariant. Glucagon signals increased levels of cAMP and severely diminishes lipogenesis. Insulin partially counteracts both glucagon effects.

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Authors and Affiliations

  1. Laboratory of Veterinary Biochemistry, State University of Utrecht, Biltstraat 172, Utrecht, The Netherlands

    Math J. H. Geelen & Willem J. Vaartjes

  2. Department of Biochemistry, Indiana University School of Medicine, 46202, Indianapolis, IN

    David M. Gibson

Authors
  1. Math J. H. Geelen
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  2. Willem J. Vaartjes
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  3. David M. Gibson
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Geelen, M.J.H., Vaartjes, W.J. & Gibson, D.M. Levels of cyclic 3′-5′-adenosine monophosphate (cAMP) in maintenance cultures of rat hepatocytes in response to insulin and glucagon. Lipids 12, 577–580 (1977). https://doi.org/10.1007/BF02533384

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  • DOI: https://doi.org/10.1007/BF02533384

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