Skip to main content
SpringerLink
Log in

Heart mitochondrial metabolism after feeding herring oil to rats and monkeys

  • Published:
Lipids

Abstract

Heart mitochondrial oxidation of palmityl CoA and pyruvic acid was studied in rats and in the monkeyMacaca fascicularis to determine the effects of feeding partially hydrogenated herring oil. Herring oil glycerides contain cetoleic acid (cis-11-docosenoic) which could have a similar effect to erucic acid (cis-13-docosenoic) in causing a rat cardiomyopathy. The initial rat heart mitochondrial response to dietary cetoleic acid (67%cis, 33%trans) was an in vitro decrease in palmityl CoA oxidation. Prolonged feeding of cetoleic acid mixture was associated with a significant metabolic adaptation, increasing pyruvate and palmityl CoA oxidation above control levels. In vitro addition of cetoleyl CoA (purecis isomer) stimulated pyruvate dehydrogenase activity, a possible response to decreased β-oxidation. There was no significant adaptive change in pyruvate or palmityl CoA use in monkeys after prolonged feeding of partially hydrogenated herring oil. Cetoleyl CoA was a good substrate for monkey heart carnitine acyl transferase even in the presence of palmityl CoA. These observations suggest that C22 fatty acids may be matabolized more rapidly in monkey heart than in rat heart. Metabolic differences argue against using the rat as an experimental model for studying possible cardiotoxic effects of docosenoic acids in primates.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Ackman, R.G., Lipids 9:1032 (1974).

    Article  PubMed  CAS  Google Scholar 

  2. Abdellatif, A.M., and R.O. Vles, Nutr. Netab. 12:285 (1970).

    Article  CAS  Google Scholar 

  3. Beare-Rogers, J.L., E.A. Nera, and H.A. Heggtveit, Can. Inst. Food Technol. J. 4:120 (1971).

    CAS  Google Scholar 

  4. Astorg, P., and G. Rocquelin, C.R. Acad. Sci. 227:797 (1973).

    CAS  Google Scholar 

  5. Kramer, J.K.G., S. Mahadevan, J.R. Hunt, F.D. Sauer, A.H. Corner, and K.M. Charlton, J. Nutr. 103:1696 (1973).

    PubMed  CAS  Google Scholar 

  6. Heijkenskjold, L., and L. Ernster, Acta Med. Scand. Suppl. 585:75 (1975).

    CAS  Google Scholar 

  7. Christophersen, B.O., and J. Bremer, Biochim. Biophys. Acta 280:506 (1972).

    PubMed  CAS  Google Scholar 

  8. Swarttouw, M.A., Biochim. Biophys. Acta 337:13 (1974).

    PubMed  CAS  Google Scholar 

  9. Beare-Rogers, J.L., and E. Gordon, Lipids 11:287 (1976).

    PubMed  CAS  Google Scholar 

  10. Christophersen, B.O., and R.Z. Christiansen, Biochim. Biophys. Acta 338:402 (1975).

    Google Scholar 

  11. Cheng, C.K., and S.V. Pande, Lipids 10:335 (1975).

    Article  PubMed  CAS  Google Scholar 

  12. Houtsmuller, V.M.T., C.G. Struijk, and A. van der Beek, Biochim. Biophys. Acta 218:564 (1970).

    PubMed  CAS  Google Scholar 

  13. Dow-Walsh, D.S., S. Mahadevan, J.K.G. Kramer, and F.D. Sauer, Ibid. 396:124 (1975).

    Google Scholar 

  14. Loew, F.M., B. Schiefer, V. Laxdal, K. Prasad, G.W. Forsyth, R.G. Ackman, E.D. Olfert, and J.M. Bell, Nutr. Metab. (In press).

  15. Pande, S.V., and M.C. Blanchaer, J. Biol. Chem. 246:402 (1971).

    PubMed  CAS  Google Scholar 

  16. Bligh, E.G., and W.J. Dyer, Can. J. Biochem. Physiol. 37:911 (1959).

    PubMed  CAS  Google Scholar 

  17. Zak, B., and J. Cohen, Clin. Chim. Acta 6:665 (1961).

    Article  PubMed  CAS  Google Scholar 

  18. Duncan, D.G., Biometrics 11:1 (1955).

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Veterinary Physiological Sciences, University of Saskatchewan, S7N 0W0, Saskatoon, Saskatchewan, Canada

    G. W. Forsyth, K. E. Carter & F. M. Loew

  2. Environment Canada, Fisheries and Marine Service, Halifax Laboratory, B3J 2R3, Halifax, Nova Scotia, Canada

    R. G. Ackman

Authors
  1. G. W. Forsyth
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. K. E. Carter
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. F. M. Loew
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. R. G. Ackman
    View author publications

    You can also search for this author in PubMed Google Scholar

About this article

Cite this article

Forsyth, G.W., Carter, K.E., Loew, F.M. et al. Heart mitochondrial metabolism after feeding herring oil to rats and monkeys. Lipids 12, 791–796 (1977). https://doi.org/10.1007/BF02533266

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02533266

Keywords

Search

Navigation