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In vitro desaturation of 1-14C linoleic acid in Novikoff hepatoma

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Lipids

Abstract

The lipid fatty acid pattern of normal liver, host liver, and Novikoff hepatoma was determined by gas liquid chromatography, and Δ6-desaturase activity for linoleic acid was measured in the microsomal fractions. The results showed that, in Novikoff hepatoma, there is a correlation between the low content of arachidonic acid and the low activity of Δ6-desaturase, a key enzyme in the biosynthetic pathway of this acid.

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Authors and Affiliations

  1. Cátedra de Bioquímica Instituto de Fisiología, Facultad de Ciencias Médicas, La Plata, Argentina

    Liliana Chiappe, Osvaldo Mercuri & María Elena Detomás

Authors
  1. Liliana Chiappe
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  2. Osvaldo Mercuri
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  3. María Elena Detomás
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Chiappe, L., Mercuri, O. & Detomás, M.E. In vitro desaturation of 1-14C linoleic acid in Novikoff hepatoma. Lipids 9, 360–362 (1974). https://doi.org/10.1007/BF02533115

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  • DOI: https://doi.org/10.1007/BF02533115

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