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Protective effect of 3-hydroxy-3-methylglutaric acid in alcohol-induced lipemia

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Lipids

Abstract

Oral administration of 1 g of 3-hydroxy-3-methylglutaric acid (HMG) before the ingestion of whiskey and a fatty meal markedly reduced the elevation of serum triglycerides, β-lipoproteins, phospholipids, and cholesterol in man. In rats receiving an ethanol and corn oil mixture, HMG also inhibited the increase in postprandial serum and liver lipids. A comparative study of HMG and nicotinic acid in rats showed that, therapeutically, 50 mg MHG/kg body weight is equivalent to 200 mg nicotinic acid/kg body weight in offering almost total protection against lipemic effects of ethanol.

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Authors and Affiliations

  1. Department of Chemistry (Division of Biochemistry), J.N. Medical College, 202001, Aligarh, Aligarh Muslim University, India

    S. Y. K. Yousufzai, Majid Siddiqi & A. K. Abdullah

  2. Department of Medicine, J.N. Medical College, 202001, Aligarh, Aligarh Muslim University, India

    S. Y. K. Yousufzai, Majid Siddiqi & A. K. Abdullah

Authors
  1. S. Y. K. Yousufzai
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  2. Majid Siddiqi
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  3. A. K. Abdullah
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Additional information

U.S. Patent 3,629,449 (Dec. 21, 1971) on “Process of Combatting Hypercholesterolemia”.

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Yousufzai, S.Y.K., Siddiqi, M. & Abdullah, A.K. Protective effect of 3-hydroxy-3-methylglutaric acid in alcohol-induced lipemia. Lipids 11, 526–529 (1976). https://doi.org/10.1007/BF02532897

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  • DOI: https://doi.org/10.1007/BF02532897

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