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Kinetics of absorption, equilibration (or distribution), and excretion of orally and intraperitoneally administered cholesterol in the rat

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Lipids

Abstract

Resorption and metabolism of cholesterol administered intraperitoneally and per os have been described in the rat utilizing a technique of double isotopic labeling. Depending upon the route of administration, these parameters vary to a large degree. Alimentary cholesterol is progressively resorbed over a period of 10 hr, while the maximal blood level of cholesterol is attained after the 6th hr following intraperitoneal injection. On the other hand, cholesterol administered per os is more rapidly utilized in biliary acid synthesis than cholesterol administered intraperitoneally. In the range of concentrations utilized in this work (10–300 μg and 0.2–300 μg, respectively, administered to the rat, orally and intraperitoneally), the rate of cholesterol resorption remained constant.

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References

  1. Chevallier, F., Adv. Lipid Res. 5:209 (1967).

    PubMed  CAS  Google Scholar 

  2. Grundy, S., and E. Ahrens, J. Lipid Res. 10:91 (1969).

    PubMed  CAS  Google Scholar 

  3. Nair, P., M. Gordon, S. Tepper, and D. Kritchensky, J. Biol. Chem. 243:4034 (1968).

    PubMed  CAS  Google Scholar 

  4. Mitropoulos, K., N. Myant, G. Gibbons, S. Balasubramaniam, and B. Reeves, Ibid. 249:6052 (1974).

    PubMed  CAS  Google Scholar 

  5. Balasubramaniam, S., K. Mitropoulos, and N. Myant, Eur. J. Biochem. 34:77 (1973).

    Article  PubMed  CAS  Google Scholar 

  6. Van Cantfort, J., and J. Gielen, Ibid. 55:33 (1975).

    Article  PubMed  Google Scholar 

  7. Van Cantfort, J., C.R. Acad. Sci. (Paris) 275:1015 (1972).

    Google Scholar 

  8. Adam, A., and J. Van Cantfort, J. Appl. Radiat. Isotopes (In press).

  9. Van Cantfort, J., J. Renson, and J. Gielen, Eur. J. Biochem. 55:23 (1975).

    Article  PubMed  Google Scholar 

  10. Levin, S., G. Johnston, and I. Boyle, Anal. Chem. 33:1407 (1961).

    Article  CAS  Google Scholar 

  11. Nakayama, F., J. Lab. Clin. Med. 69:594 (1967).

    PubMed  CAS  Google Scholar 

  12. Adam, A., Ph.D. Thesis, University of Liege, Liege, Belgium, 1974, pp. 55–89.

  13. Sodhi, H.S., R.C. Orchard, N.D. Agnish, P.V. Varughese, and B.J. Kudchodkar, Atherosclerosis 17:197 (1973).

    Article  PubMed  CAS  Google Scholar 

  14. Rosenfeld, R.S., B. Zumoff, and L. Hellman, Ibid. 13:77 (1971).

    Article  PubMed  CAS  Google Scholar 

  15. Ogura, M., J. Shiga, and K. Yamasaki, J. Biochem. 70:967 (1971).

    PubMed  CAS  Google Scholar 

  16. Feldman, E., Biochem. Med. 2:136 (1968).

    Article  CAS  Google Scholar 

  17. Gebhard, R., and H. Buchwald, Surgery 67:474 (1970).

    PubMed  CAS  Google Scholar 

  18. Bjorkhem, I., and H. Danielsson, Eur. J. Biochem. 53:63 (1975).

    Article  CAS  Google Scholar 

Download references

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Author notes

  1. A. Adam

    Present address: Centre hospitalier de Sainte-Ode, B-6970, Tenneville, Belgium

Authors and Affiliations

  1. Laboratoire de Chimie Médicale, 151, Bd. de la Constitution, B-4020, Liège, Belgium

    A. Adam, J. Van Cantfort & J. Gielen

Authors
  1. A. Adam
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  2. J. Van Cantfort
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  3. J. Gielen
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Adam, A., Van Cantfort, J. & Gielen, J. Kinetics of absorption, equilibration (or distribution), and excretion of orally and intraperitoneally administered cholesterol in the rat. Lipids 11, 610–615 (1976). https://doi.org/10.1007/BF02532874

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  • DOI: https://doi.org/10.1007/BF02532874

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