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An unidentified lipid prevalent in tumors

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Lipids

Abstract

An unidentified lipid was found in five different tumor sources. It was not found in liver, bone marrow or plasma from tumor-bearing animals, nor in the extracellular fluid supporting growth of Ehrlich ascites cells. The polarity of the unidentified component was similar to that of a glyceryl ether diester, and it was isolated in milligram amounts by preparative thinlayer chromatography. Neither methyl esters of fatty acids, vinyl ether diesters nor quinones were found in the structural makeup of this lipid. Thin-layer chromatography of the purified unidentified tumor lipid on Ag-impregnated silica layers revealed two main components of intermediary unsaturation. Saponification of the unidentified tumor lipid, when water washing was omitted, yielded two components that migrated at Rf's identical to those of free fatty acids and dihydroxy glyceryl monoethers. Neither acetate-1-14C nor palmitic-1-14C acid (single injections) was found to be incorporated into the unidentified lipid of a mature rat tumor.

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References

  1. David, H., and R. J. Rossiter, Canadian J. Biochem.42, 299 (1964).

    Article  CAS  Google Scholar 

  2. DiPaolo, J. A., A. Heining and C. Carruthers, Proc. Soc. Exp. Biol. Med.113, 68 (1963).

    PubMed  CAS  Google Scholar 

  3. Yamakawa, T., N. Ueta and R. Irie, I., Jap. J. Exp. Med.32, 289 (1962).

    PubMed  CAS  Google Scholar 

  4. Marinetti, G. V., and E. M. Kay, Biochem. Biophys. Acta70, 168 (1963).

    Article  CAS  Google Scholar 

  5. Lindlar, F., and H. Wagener, Schweiz. Med. Wschr.94, 243 (1964).

    PubMed  CAS  Google Scholar 

  6. Gerstl, B., R. B. Hayman, P. Ramorino, M. G. Tavaststjerna and J. K. Smith, Am. J. Clin. Path.43, 314 (1965).

    PubMed  CAS  Google Scholar 

  7. Kosaki, T., T. Ikoda, Y. Kotani, S. Nakagawa and T. Saka. Science129, 1176 (1958).

    Article  Google Scholar 

  8. Gray, G. M., Biochem. J.81, 30P (1961).

  9. Kamar, V. B., Nature196, 1206 (1962).

    Article  Google Scholar 

  10. Kogl, F., C. Smak, J. H. Veerkamp and L. L. M. van Deenen, Z. Krebsforsch63, 558 (1960).

    Article  PubMed  CAS  Google Scholar 

  11. Folch, J., M. Lees and G. H. Sloane Stanley, J. Biol. Chem.226, 497 (1957).

    PubMed  CAS  Google Scholar 

  12. Wood, R., and F. Snyder, JAOCS43, 53 (1966).

    CAS  Google Scholar 

  13. Dilley, R. A., Anal. Biochem.7, 240 (1964).

    Article  PubMed  CAS  Google Scholar 

  14. Snyder, F., and H. Kimble, Anal. Biochem.11, 510 (1965).

    Article  PubMed  CAS  Google Scholar 

  15. Baumann, W. J., and H. K. Mangold, Biochim. Biophys. Acta116, 570 (1966).

    PubMed  CAS  Google Scholar 

  16. Norton, W. T., Nature184, 1144 (1959).

    Article  PubMed  CAS  Google Scholar 

  17. Piantadosi, C., A. F. Hirsch, C. L. Yarbro and C. E. Anderson, J. Org. Chem.28, 2425 (1963).

    CAS  Google Scholar 

  18. Schmid, H. H. O. and H. K. Mangold, Biochim. Biophys. Acta,125, 182 (1966).

    CAS  Google Scholar 

  19. Schmid, H. H. O. and H. K. Mangold, Biochem. Zeit., in press (1966).

  20. Price, S. P., Science128, 45 (1958).

    Article  Google Scholar 

Download references

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Authors and Affiliations

  1. Medical Division, Oak Ridge Institute of Nuclear Studies, Oak Ridge, Tennessee

    Fred Snyder, Edgar A. Cress & Nelson Stephens

Authors
  1. Fred Snyder
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  2. Edgar A. Cress
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  3. Nelson Stephens
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Under contract with US Atomic Energy Commission.

An operating unit of Oak Ridge Associated Universities.

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Snyder, F., Cress, E.A. & Stephens, N. An unidentified lipid prevalent in tumors. Lipids 1, 381–386 (1966). https://doi.org/10.1007/BF02532540

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  • DOI: https://doi.org/10.1007/BF02532540

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