European Journal of Pediatrics

, Volume 155, Issue 12, pp 1031–1034 | Cite as

Influence of recombinant interferon alpha on nutritional status and growth pattern in children with chronic viral hepatitis

  • F. Gottrand
  • L. Michaud
  • D. Guimber
  • S. Ategbo
  • G. Dubar
  • D. Turck
  • J. P. Farriaux
Infectious Diseases

Abstract

Abstract

Anorexia and weight loss are frequently reported as adverse effects during recombinant interferon α (rIFN-α) treatment. The aim of the present study was to assess both nutritional status and growth of children and adolescents treated with rIFN-α for chronic viral hepatitis. Eleven patients aged 4–16 years with histologically proven chronic active hepatitis (hepatitis B,n=9; hepatitis C,n=2) receiving rIFN-α subcutaneously thrice a week for 6 months were studied. Weight and height increments were assessed during the 6 months before starting iIFN-α. Weight and height were measured every 3 months (M0, M3, M6) during the 6 months of rIFN-α treatment, then every 6 months during the follow up period (6–36 months). Weight decreased in every child during rIFN-α treatment (weight loss varies from 0.5 to 2.6 kg after 3 months of treatment). Weight/age Z-score decreased from 0.12 at M0 to −0.69 at M3 (P<0.01), then increased between M3 and M6 (−0.33) (P<0.01), but normalized (0.02) only 6 months after completion of treatment. Nutritional status was significantly impaired during treatment (Z-score for weight/height decreased from 0.18 at M0 to −0.74 at M3,P<0.01) and recovered progressively thereafter. Height and height velocity were not modified by rIFN-α treatment. A reduction of the caloric intake observed between M0 and M3 might explain these features.

Conclusion

Significant but transient abnormalities of the nutritional status are encountered constantly at the beginning of rIFN-α therapy without any deleterious effect on growth. Information of the families and nutritional intervention during treatment should be required, in order to limit the importance of weight loss.

Key words

Interferon-alfarecombinant Children Growth Hepatitis B therapy Hepatitis C therapy 

Abbreviations

rIFN

recombinant interferon α

HBV

hepatitis B virus

HCV

hepatitis C virus

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Bruguera M, Amat L, Garcia O, Lambruschini N, Carnicer J, Bergada A, Orte EM, Costa J, Sanchez-Tapias JM, Rodes J (1993) Treatment of chronic hepatitis B in children with recombinant alfa interferon. Different response according to age at infection. J Clin Gastroenterol 17:296–299PubMedCrossRefGoogle Scholar
  2. 2.
    Cesaro S, Rossetti F, De Moliner L, Crivellaro C, Zanesco L, Bortolotti F (1994) Interferon for chronic hepatis C in patients cured of malignancy. Eur J Pediatr 153:659–662PubMedCrossRefGoogle Scholar
  3. 3.
    Conjcevaram, Di Bisceglie AM (1995) Management of chronic viral hepatitis in children. J Pediatr Gastroenterol Nutr 20:365–375Google Scholar
  4. 4.
    Cullu F, Tumay GT, Kutlu T, Erkan T, Ozbay G, Badur S (1995) Traitement de l'hépatite chronique à virus B de l'enfant par des doses modérées d'interféron alpha. Gastroentérol Clin Biol 19:53–57PubMedGoogle Scholar
  5. 5.
    Fujisawa T, Inui A, Ohkawa T, Komatsu H, Miyakawa Y, Onoue M (1995) Response to interferon therapy in children with chronic hepatitis C. J Pediatr 127:660–662PubMedCrossRefGoogle Scholar
  6. 6.
    Giacchino R, Main J, Timitilli A, Giambartolomei G, Facco F, Cirillo C, Jacyna MR, Brook MG, Callea F, Kariayannis P, Terragna A, Thomas HC (1995) Dual-center, double blind, randomized trial of lymphoblastoid interferon alpha with or without steroid pretreatment in children with chronic hepatitis B. Liver 15:143–148PubMedGoogle Scholar
  7. 7.
    Lai CL, Lin HJ, Yeoh EK, Lok ASF, Wu PC, Yeung CY (1987) Placebocontrolled trial of recombinant a2-interferon in chinese HBsAg-carrier children. Lancet II:877–880CrossRefGoogle Scholar
  8. 8.
    Marcellin P, Benhamou JP (1994) Treatment of chronic viral hepatitis. Baillieres Clin Gastroenterol 8:233–253PubMedCrossRefGoogle Scholar
  9. 9.
    Ruiz-Moreno M, Rua MJ, Molina J, Moraleda G, Moreno A, Garcia-Aguado J, Carreno V (1991) Prospective, randomized controlled trial of interferon-α in children with chronic hepatitis B. Hepatology 13:1035–1039PubMedCrossRefGoogle Scholar
  10. 10.
    Ruiz-Moreno M, Rua MJ, Castillo I, Garcia-Novo MD, Santos M, Navas S, Carreno V (1992) Treatment of children with chronic hepatitis C with recombinant interferon-α: a pilot study. Hepatology 16:882–885PubMedGoogle Scholar
  11. 11.
    Sokal EM, Wirth S, Goyens P, Depreterre A, Cornu C (1993) Interferon alfa-2b therapy in children with chronic hepatitis B. Gut [Suppl]:S87–S90Google Scholar
  12. 12.
    Utili R, Sagnelli E, Galanti B, Aprea L, Cesaro G, Digilio L, Filippini P, Felaco FM, Gaeta GB, Marrone A, Nardiello S, Pasquale G, Piccinino F, Pizzella T, Ruggiero G, Russo M, Santarpia L, Sardaro C, Giusti G (1991) Prolonged treatment of children with chronic hepatitis B with recombinant α2a-interferon: a controlled, randomized study. Am J Gastroenterol 86:327–330PubMedGoogle Scholar
  13. 13.
    Utili R, Sagnelli E, Gaeta GB, Galanti B, Nardiello S, Felaco FM, Pasquale G, Marrone A, Aprea L, Pizzella T, Digilio L, Cesaro G, Sardaro C, Santarpia L, Adinolfi LE, Andreana A, Russo M, Filippini P, Zampino R, Piccinino F, Ruggiero G, Giusti G (1994) Treatment of chronic hepatitis B in children with prednisone followed by alfa-interferon: a controlled randomized study. J Hepatol 20:163–167PubMedCrossRefGoogle Scholar
  14. 14.
    Vegnente A, Guida S, Di Constanzo V, Fusco C, Iorio R, Toscano P (1992) Nutritional status and growth in children with chronic hepatitis B. J Pediatr Gastroenterol Nutr 14:123–127PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag 1996

Authors and Affiliations

  • F. Gottrand
    • 1
  • L. Michaud
    • 1
  • D. Guimber
    • 1
  • S. Ategbo
    • 1
  • G. Dubar
    • 1
  • D. Turck
    • 1
  • J. P. Farriaux
    • 1
  1. 1.Service de Pédiatrie Hôpital HuriezCHRU de LilleLilleFrance

Personalised recommendations