Skip to main content
SpringerLink
Log in

Metabolism of linolenic acid in developing brain: I. Incorporation of radioactivity from 1-14C linolenic acid into brain fatty acids

  • Published:
Lipids

Abstract

Twelve-thirteen day old rats were given 1-14C linolenic acid by intraperitoneal injection. Fatty acids were isolated from the brains of animals sacrificed at the end of 8 and 48 hr and 15 and 45 days. Eight hr after the tracer, radioactivity was found neither in 18∶3 nor its endproduct, 22∶6, and palmitate was the most highly radioactive component. At longer intervals, 22∶6 seemed to retain much of the radioactivity, whereas palmitate showed a precipitous decline in radioactivity. Initial oxidation of linolenate and sparing of the linolenate complexed with polar lipids are discussed.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Kirschman, J.C., and J.G. Coniglio, Arch. Biochem. Biophys. 93:297 (1961).

    Article  CAS  Google Scholar 

  2. Rouser, G., and A. Yamamoto, in “Handbook of Neurochemistry,” Vol. 1, Edited by A. Lajtha, Plenum Press, New York, N.Y., 1969, p. 121.

    Google Scholar 

  3. O'Brien, J.S., and E.L. Sampson, J. Lipid Res. 6:545 (1965).

    PubMed  Google Scholar 

  4. Dhopeshwarkar, G.A., and J.F. Mead, Biochim. Biophys. Acta 187:461 (1969).

    PubMed  CAS  Google Scholar 

  5. Sun, G.Y., and L.A. Horrocks, Lipids 3:79 (1968).

    Article  CAS  PubMed  Google Scholar 

  6. Miyamoto, K., L.M. Stephanides, and J. Bernsohn, J. Neurochem. 14:227 (1967).

    Article  PubMed  CAS  Google Scholar 

  7. Dhopeshwarkar, G.A., C. Subramanian, and J.F. Mead, Biochim. Biophys. Acta 239:162 (1971).

    PubMed  CAS  Google Scholar 

  8. Folch, J., M. Lees, and G.H. Sloane Stanley, J. Biol. Chem. 226:497 (1957).

    PubMed  CAS  Google Scholar 

  9. Stein, R.A., and V. Slawson, Anal. Chem. 40:2017 (1968).

    Article  CAS  Google Scholar 

  10. Kishimoto, Y., and N.S. Radin, Lipids 1:47 (1966).

    CAS  PubMed  Google Scholar 

  11. Vignais, P.M., C.H. Gallagher, and I. Zabin, J. Neurochem. 2:283 (1958).

    PubMed  CAS  Google Scholar 

  12. Beattie, D.S., and R.E. Basford, J. Neurochem. 12:103 (1965).

    PubMed  CAS  Google Scholar 

  13. Marquis, N.S., and I.B. Fritz, J. Lipid Res. 5:184 (1964).

    PubMed  CAS  Google Scholar 

  14. Dhopeshwarkar, G.A., and J.F. Mead, Biochim. Biophys. Acta 210:250 (1970).

    PubMed  CAS  Google Scholar 

  15. Dhopeshwarkar, G.A., C. Subramanian, and J.F. Mead, Ibid. 231:8 (1971).

    PubMed  CAS  Google Scholar 

  16. Hajra, A.K., and N.S. Radin, J. Lipid Res. 4:448 (1963).

    PubMed  CAS  Google Scholar 

  17. Dhopeshwarkar, G.A., C. Subramanian, and J.F. Mead, Biochim. Biophys. Acta 296:257 (1973).

    PubMed  CAS  Google Scholar 

  18. Goransson, G., Acta Physiol. Scand. 64:1 (1965).

    Article  CAS  Google Scholar 

  19. Coots, R.H., J. Lipid Res. 6:494 (1965).

    PubMed  CAS  Google Scholar 

  20. Brown, W.D., and A.L. Tappel, Arch. Biochem. Biophys. 85:149 (1959).

    Article  PubMed  CAS  Google Scholar 

  21. Klenk, E., in “Drugs Affecting Lipid Metabolism,” Edited by S. Garattini and R. Paoletti, Elsevier Press, Amsterdam, The Netherlands, 1961, p. 21.

    Google Scholar 

  22. D'Adamo, A.F., Jr., in “Handbook of Neurochemistry,” Vol. 3, Edited by A. Lajtha, Plenum Press, New York, N.Y., 1970, p. 525.

    Google Scholar 

  23. Sinclair, A.J., and M.A. Crawford, J. Neurochem. 19:1753 (1972).

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Laboratory of Nuclear Medicine and Radiation Biology and Division of Environmental and Nutritional Sciences, UCLA School of Public Health, 90024, Los Angeles, California

    Govind A. Dhopeshwarkar

  2. Laboratory of Nuclear Medicine and Radiation Biology, University of California, 90024, Los Angeles, California

    Carole Subramanian

Authors
  1. Govind A. Dhopeshwarkar
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Carole Subramanian
    View author publications

    You can also search for this author in PubMed Google Scholar

About this article

Cite this article

Dhopeshwarkar, G.A., Subramanian, C. Metabolism of linolenic acid in developing brain: I. Incorporation of radioactivity from 1-14C linolenic acid into brain fatty acids. Lipids 10, 238–241 (1975). https://doi.org/10.1007/BF02532486

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02532486

Keywords

Search

Navigation