, Volume 10, Issue 9, pp 571–573 | Cite as

Bile acid metabolism in mammals: IX. Conversion of chenodeoxycholic acid to cholic acid by isolated perfused rat liver

  • I. M. Yousef
  • M. M. Fisher
Short Communications


Current dogma of bile acid synthesis in mammals insits that hydroxylation of the ring structure at C-12 precedes side chain oxidation, and that chenodeoxycholic acid is not converted to cholic acid under normal conditions. This report concerns the conversion of chenodeoxycholic acid to cholic acid by isolated, perfused rat liver. Results indicate that isolated perfused rat liver has a definite, but limited, capacity for synthesis of cholic acid from chenodeoxycholic acid.


Bile Acid Cholic Acid Chenodeoxycholic Acid Perfusion Medium Bile Acid Synthesis 
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Copyright information

© American Oil Chemists’ Society 1975

Authors and Affiliations

  • I. M. Yousef
    • 1
  • M. M. Fisher
    • 1
  1. 1.Department of Pathology and MedicineUniversity of TorontoTorontoCanada

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