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New drugs affecting lipid metabolism

  • Symposium: Effect of Drugs on Lipid Metabolism Presented at the AOCS Spring Meeting, New Orleans
  • Published:
Lipids

Abstract

The search for an ideal hypolipidemic agent still is underway. A relatively large number of the newer hypolipemic agents are related to ethyl p-chlorophenoxyisobutyrate—among them are compounds with the trivial names or designations of SU 13,437; Sah 42-348; halofenate, treloxinate, S-8527, and two valeric acid derivatives. Other lipopenic agents, whose modes of action are described, are linoleic acid amides, Colestipol, antidiabetic agents, bis (hydroxyethylthio) 1,10-decane, pyridinol carbamate, and some nicotinic acid derivatives.

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References

  1. Avoy, D.R., E.A. Swyryd, and R.G. Gould, J. Lipid Res. 6:369 (1965).

    PubMed  CAS  Google Scholar 

  2. Azarnoff, D.L., D.R. Tucker, and G.A. Barr, Metabolism 14:959 (1965).

    Article  PubMed  CAS  Google Scholar 

  3. Nestel, P.J., E.Z. Hirsch, and E.A. Couzens, J. Clin. Invest. 44:891 (1965).

    Article  PubMed  CAS  Google Scholar 

  4. Grundy, S.M., E.H. Ahrens, Jr., G. Salen, P.H. Schreibman, and P.J. Nestel, J. Lipid Res. 13:531 (1972).

    PubMed  CAS  Google Scholar 

  5. Duncan, C.H., M.M. Best, and R.J. Lubbe, Metabolism 13:1 (1964).

    Article  PubMed  CAS  Google Scholar 

  6. Failey, R.B., Jr., E. Brown, and M.E. Hodes, Amer. J. Clin. Nutr. 11:4 (1962).

    CAS  Google Scholar 

  7. Kritchevsky, D., Fed. Proc. 30:835 (1971).

    PubMed  CAS  Google Scholar 

  8. Hess, R., and W.L. Bencze, Experientia 24:418 (1968).

    Article  PubMed  CAS  Google Scholar 

  9. Kritchevsky, D., and S.A. Tepper, Ibid. 25:699 (1969).

    Article  PubMed  CAS  Google Scholar 

  10. Hartmann, G., and G. Forster, J. Atheroscler. Res. 10:235 (1969).

    PubMed  CAS  Google Scholar 

  11. Oriente, P., M. Motolese, R. Cerqua, and M. Mancini, Int. Z. Klin. Pharmakol. Therap. Toxikol. 2:348 (1969).

    CAS  Google Scholar 

  12. Weiss, P., C.A. Dujovne, S. Margolis, L. Lasagna, and J.L. Bianchine, Clin. Pharmacol. Ther. 11:90 (1970).

    PubMed  CAS  Google Scholar 

  13. Timms, A.R., L.A. Kelly, R.S. Ho, and J.H. Trapold, Biochem. Pharmacol. 18:1861 (1969).

    Article  PubMed  CAS  Google Scholar 

  14. Kritchevsky, D., and S.A. Tepper, Arzneimittelforsch 6:858 (1973).

    Google Scholar 

  15. Berkowitz, D., Circulation 40 suppl. 3:44 (1969).

    Google Scholar 

  16. Gilfillan, J.L., V.M. Hunt, and J.W. Huff, Proc. Soc. Exp. Biol. Med. 136:1274 (1971).

    PubMed  CAS  Google Scholar 

  17. Kritchevsky, D., and S.A. Tepper, Ibid. 139:1284 (1972).

    PubMed  CAS  Google Scholar 

  18. Kritchevsky, D., S.A. Tepper, P. Sallata, J.R. Kabakjian, and V.J. Cristofalo, Ibid. 132:76 (1969).

    CAS  Google Scholar 

  19. Whitehouse, M.W., E. Staple, and S. Gurin, J. Biol. Chem. 234:276 (1959).

    PubMed  CAS  Google Scholar 

  20. Kariya, T., T.R. Blohm, J.M. Grisar, R.A. Parker, and J.R. Martin, Adv. Exp. Med. Biol. 26:302 (1972).

    Google Scholar 

  21. Grisar, J.M., R.A. Parker, T. Kariya, T.R. Blohm, R.W. Fleming, V. Petrow, D.L. Wenstrup, and R.G. Johnson, J. Med. Chem. 15:1273 (1972).

    Article  PubMed  CAS  Google Scholar 

  22. Toki, K., Y. Nakamura, K. Agatsuma, H. Nakatani, and S. Aono, Atherosclerosis 18:101 (1973).

    Article  PubMed  CAS  Google Scholar 

  23. Kritchevsky, D., and S.A. Tepper, Ibid. 18:93 (1973).

    Article  PubMed  CAS  Google Scholar 

  24. Story, J.A., S.A. Tepper, and D. Kritchevsky, Fed. Proc. 32:690 (abs.) (1973).

    Google Scholar 

  25. Toki, K., and H. Nakatani, Adv. Exp. Med. Biol. 4:491 (1969).

    CAS  Google Scholar 

  26. Kritchevsky, D., and S.A. Tepper, J. Atheroscler. Res. 7:527 (1967).

    PubMed  CAS  Google Scholar 

  27. Fukushima, H., S. Aono, Y. Nakamura, M. Endo, and T. Imai, Ibid. 10:403 (1969).

    PubMed  CAS  Google Scholar 

  28. Nakatani, H., H. Fukushima, A. Wakimura, and M. Endo, Science 153:1267 (1966).

    Article  PubMed  CAS  Google Scholar 

  29. Parkinson, T.M., K. Gunderson, and N.A. Nelson, Atherosclerosis 11:531 (1970).

    Article  PubMed  CAS  Google Scholar 

  30. Kritchevsky, D., H.K. Kim, and S.A. Tepper, Proc. Soc. Exp. Biol. Med. 142:185 (1973).

    PubMed  CAS  Google Scholar 

  31. Agid, A., and G. Marquie, “La Via Metabolica Dell’ Aterogenesi,” Edited by G. Labo, Casa Editrice R. Patron, Bologna, Italy, 1972, p. 579.

    Google Scholar 

  32. Czyzyk, A., A. Ostaszynski, H. Plenkiewicz, Z. Szczepanik, and T. Urbanski, Arzneimittelforsch 22:465 (1972).

    PubMed  CAS  Google Scholar 

  33. Assous, E., M. Pouget, J. Nadaud, G. Tartary, M. Henry, and J. Duteil, Therapie 27:395 (1972).

    PubMed  CAS  Google Scholar 

  34. Debray, C., C. Vaille, C. Roze, and M. Souchard, Ibid. 27:423 (1972).

    PubMed  CAS  Google Scholar 

  35. Rouffy, J., and J. Loeper, Ibid. 27:433 (1972).

    PubMed  CAS  Google Scholar 

  36. Altschul, R., A. Hoffer, and J.D. Stephen, Arch. Biochem. Biophys. 54:558 (1955).

    Article  CAS  Google Scholar 

  37. Carlson, L.A., C. Hedbom, E. Helgstrand, B. Sjöberg, and N.E. Stjernström, Adv. Exp. Med. Biol. 4:85 (1969).

    CAS  Google Scholar 

  38. Carlson, L.A., C. Hedbom, E. Helgstrand, A. Misiorny, B. Sjöberg, N.E. Stjernström, and G. Westin, Acta Pharm. Suecica 9:221 (1972).

    CAS  Google Scholar 

  39. Carlson, L.A., C. Hedbom, E. Helgstrand, B. Sjöberg, and N.E. Stjernström, Ibid. 9:289 (1972).

    CAS  Google Scholar 

  40. Carlson, L.A., C. Hedbom, E. Helgstrand, A. Misiorny, B. Sjöberg, N.E. Stjernström, and G. Westin, Ibid. 9:411 (1972).

    CAS  Google Scholar 

  41. Bailey, D.M., D. Wood, R.E. Johnson, J.P. McAuliff, J.C. Bradford, and A. Arnold, J. Med. Chem. 15:344 (1972).

    Article  PubMed  CAS  Google Scholar 

  42. Shimamoto, T., F. Numano, T. Fujita, T. Ishioka, and T. Atsumi, Asian Med. J. 8:825 (1965).

    Google Scholar 

  43. Shimamoto, T., F. Numano, and T. Fujita, Amer. Heart J. 71:216 (1966).

    Article  PubMed  CAS  Google Scholar 

  44. Shimamoto, T., T. Atsumi, F. Numano, and T. Fujita, Prog. Biochem. Pharmacol. 4:597 (1968).

    CAS  Google Scholar 

  45. Kritchevsky, D., and S.A. Tepper, Experientia 23:1006 (1967).

    Article  PubMed  CAS  Google Scholar 

  46. Kritchevsky, D., and S.A. Tepper, Arzneimittelforsch 21:146 (1971).

    PubMed  CAS  Google Scholar 

  47. Kritchevsky, D., J.T. Kolimaga, H.K. Kim, and S.A. Tepper, in “Atherogenesis II,” Edited by T. Shimamoto, C.N. Addison, and F. Numano, Excerpta Medical Foundation, Amsterdam, Holland, 1973, p. 129.

    Google Scholar 

  48. Wu, C.C., T.S. Huang, and C.J. Hsu, Amer. Heart J. 77:657 (1969).

    Article  PubMed  CAS  Google Scholar 

  49. Sanwald, R., and H. Wagener, Adv. Exp. Med. Biol. 26:318 (1972).

    Google Scholar 

  50. Möttönen, M., M. Pantio, and L. Nieminen, Atherosclerosis 15:77 (1972).

    Article  PubMed  Google Scholar 

  51. Malinow, M.R., A. Perley, and P. McLaughlin, J. Atheroscler. Res. 8:455 (1968).

    Article  PubMed  CAS  Google Scholar 

  52. Malinow, M.R., P. McLaughlin, and A. Perley, Atherosclerosis 15:31 (1972).

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. The Wistar Institute of Anatomy and Biology, 19104, Philadelphia, Pennsylvania

    David Kritchevsky

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  1. David Kritchevsky
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Additional information

One of six papers presented in the symposium, “Effect of Drugs on Lipid Metabolism,” AOCS Spring Meeting, New Orleans, April 1973.

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Kritchevsky, D. New drugs affecting lipid metabolism. Lipids 9, 97–102 (1974). https://doi.org/10.1007/BF02532133

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  • DOI: https://doi.org/10.1007/BF02532133

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