Skip to main content
SpringerLink
Log in

Inhibition of phospholipase C by isosteric phosphinic acid analogues of lecithin

  • Published:
Lipids

Abstract

Four synthetic diether phosphinate analogues of lecithin were studied for inhibitory activity againstClostridium perfringens phospholipase C. An order of inhibitory effectiveness of phosphonate and phosphinate was, thereby, developed. The inhibitions seem relatively independent of specific structural features; this is discussed with emphasis on physical effects which complicate the inhibition kinetics.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Rosenthal, A.F., and M. Pousada, Biochim. Biophys. Acta 164:226 (1968).

    PubMed  CAS  Google Scholar 

  2. Rosenthal, A.F., S.V. Chodsky, and S.C.H. Han, Ibid. 187:385 (1969).

    PubMed  CAS  Google Scholar 

  3. Rosenthal, A.F., and S.V. Chodsky, J. Lipid Res. 12:277 (1971).

    PubMed  CAS  Google Scholar 

  4. Rosenthal, A.F. and S.V. Chodsky, Biochim. Biophys. Acta 239:248 (1971).

    PubMed  CAS  Google Scholar 

  5. Rosenthal, A.F., L. Vargas, and S.C.H. Han, Ibid. 260:369 (1972).

    PubMed  CAS  Google Scholar 

  6. Singleton, W.S., M.S. Gray, M.L. Brown, and J.L. White, JAOCS 42:53 (1965).

    PubMed  CAS  Google Scholar 

  7. Lea, C.H., D.N. Rhodes, and R.D. Stoll, Biochim. J. 60:353 (1955).

    CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Laboratories, The Long Island Jewish-Hillside Medical Center, 11040, New Hyde Park, New York

    Arthur F. Rosenthal & Sergei V. Chodsky

Authors
  1. Arthur F. Rosenthal
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Sergei V. Chodsky
    View author publications

    You can also search for this author in PubMed Google Scholar

About this article

Cite this article

Rosenthal, A.F., Chodsky, S.V. Inhibition of phospholipase C by isosteric phosphinic acid analogues of lecithin. Lipids 9, 77–80 (1974). https://doi.org/10.1007/BF02532129

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02532129

Keywords

Search

Navigation