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Bis-(monoacylglyceryl)-phosphate of rat and human liver: Fatty acid composition and NMR spectroscopy

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Lipids

Abstract

Bis-(monoacylglyceryl)-phosphate was isolated from liver lysosomes that had been prepared from rats pretreated with Triton WR-1339. Analysis of the fatty acids in this lipid by gas chromatography and mass spectrometry revealed that they were composed of 69% docosahexenoic acid. NMR spectroscopy of bis-(monoacylglyceryl)-phosphate isolated from liver of a patient who had a lipid storage disease revealed that the peak corresponding to the chemical shift of protons of esterified secondary carbons of glycerol was absent. This suggests that fatty acids are esterified to the primary position of both glycerols.

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Authors and Affiliations

  1. Department of Medicine (Neurology), University of Toronto, 6368 Medical Sciences Building, M5B 1A8, Toronto, Canada

    J. R. Wherrett & S. Huterer

Authors
  1. J. R. Wherrett
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  2. S. Huterer
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Wherrett, J.R., Huterer, S. Bis-(monoacylglyceryl)-phosphate of rat and human liver: Fatty acid composition and NMR spectroscopy. Lipids 8, 531–533 (1973). https://doi.org/10.1007/BF02531989

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  • DOI: https://doi.org/10.1007/BF02531989

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