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Lipids

, Volume 7, Issue 9, pp 628–630 | Cite as

Effect of neonatal food restriction and hyperphenylalaninemia on desmosterol to cholesterol (D/C) ratio in developing rat brain

  • S. N. Shah
Short Communications

Abstract

The sterol content and the ratio of desmosterol to cholesterol (D/C ratio) in brains of undernourished and hyperphenylalaninemic rats were measured. Neonatal food restriction resulted in a high D/C ratio, but the total sterol content did not change significantly. Phenylalanine treatment had no appreciable effect on the D/C ratio, but the total sterol content was reduced. The results suggest that neonatal food restriction leads to a block at the desmosterol reductase step, while treatment with phenylalanine inhibits sterol synthesis at a step prior to desmosterol.

Keywords

Cholesterol Petroleum Ether Extract Desmosterol Sterol Content Cholesterol Feeding 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© American Oil Chemists’ Society 1972

Authors and Affiliations

  • S. N. Shah
    • 1
  1. 1.Brain-Behavior Research CenterSonoma State HospitalEldridge

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