, Volume 7, Issue 9, pp 628–630 | Cite as

Effect of neonatal food restriction and hyperphenylalaninemia on desmosterol to cholesterol (D/C) ratio in developing rat brain

  • S. N. Shah
Short Communications


The sterol content and the ratio of desmosterol to cholesterol (D/C ratio) in brains of undernourished and hyperphenylalaninemic rats were measured. Neonatal food restriction resulted in a high D/C ratio, but the total sterol content did not change significantly. Phenylalanine treatment had no appreciable effect on the D/C ratio, but the total sterol content was reduced. The results suggest that neonatal food restriction leads to a block at the desmosterol reductase step, while treatment with phenylalanine inhibits sterol synthesis at a step prior to desmosterol.


Cholesterol Petroleum Ether Extract Desmosterol Sterol Content Cholesterol Feeding 
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Copyright information

© American Oil Chemists’ Society 1972

Authors and Affiliations

  • S. N. Shah
    • 1
  1. 1.Brain-Behavior Research CenterSonoma State HospitalEldridge

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