Abstract
The fate of an oral dose of [4-14C] cholesterol given to rats grown on diets with 20% safflower oil or 20% hydrogenated coconut oil was determined by analysis of digestive tract, feces and tissues. The pattern of isotope distribution did not support the view that rats fed a saturated fat absorb less cholesterol than those fed an unsaturated fat. Fasted animals growth on the diet with 5% of these two fats and beef fallow showed no clear difference in the amount of digitonin-peecipitable sterol in their intestines. A shorter transit time for intestinal contents was observed with the saturated fat groups. It is concluded that neither absorption of cholesterol from the gut nor secretion of β-hydroxy sterol into the gut accounts for the hypocholesterolemic effect of polyunsaturated fat.
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References
Wood, P., R. Shioda and L. Kinsell, Lancet 2:604 (1966).
Wood, P., Y. Lee and L. Kinsell, Fed. Proc. 26:261 (1967).
Byers, S., and M. Friedman, Proc. Soc. Exp. Biol. Med. 98:523 (1958).
Bloomfield, D., J. Lab. Clin. Med. 64:613 (1964).
Klauda, H., and F. Quackenbush, Lipids 5:142 (1970).
Quqckenbush, F.W., and M. Pawlowski, J. Nutr. 72:196 (1960).
Harris, R., and D. Gambal, Anal. Biochem. 5:479 (1963).
Sperry, W.M., and M. Webb, J. Biol. Chem. 187:97 (1950).
Hofmann, A., and B. Borgstrom, J. Clin. Invest. 43:247 (1964).
Borgstrom, B., Ibid. 39:809 (1960).
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Journal Paper No. 4951 AES, Purdue University.
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Mcgovern, R.F., Quackenbush, F.W. Effect of dietary fat saturation of absorption and intestinal secretion of cholesterol by the hypercholesterolemic rat. Lipids 8, 470–472 (1973). https://doi.org/10.1007/BF02531766
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DOI: https://doi.org/10.1007/BF02531766